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Solvent Effects on the Steady-state Absorption and Fluorescence Spectra of Uracil, Thymine and 5-Fluorouracil

Authors

  • Thomas Gustavsson,

    Corresponding author
    1. Laboratoire Francis Perrin, CEA/DSM/DRECAM/SPAM – CNRS URA 2453, CEA Saclay, F-91191 Gif-sur-Yvette, France
      *email: thomas.gustavsson@cea.fr (Thomas Gustavsson)
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  • Nilmoni Sarkar,

    1. Laboratoire Francis Perrin, CEA/DSM/DRECAM/SPAM – CNRS URA 2453, CEA Saclay, F-91191 Gif-sur-Yvette, France
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    •  Current address: Department of Chemistry, Indian Institute of Technology, Kharagpur, PIN 721 302, WB, India.

  • Ákos Bányász,

    1. Laboratoire Francis Perrin, CEA/DSM/DRECAM/SPAM – CNRS URA 2453, CEA Saclay, F-91191 Gif-sur-Yvette, France
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  • Dimitra Markovitsi,

    1. Laboratoire Francis Perrin, CEA/DSM/DRECAM/SPAM – CNRS URA 2453, CEA Saclay, F-91191 Gif-sur-Yvette, France
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  • Roberto Improta

    1. Dipartimento di Chimica, Universita Federico II, Complesso Universitario Monte S. Angelo, Via Cintia, I-80126 Napoli, Italy
    2. Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 6 I-80134 Napoli, Italy
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  • This invited paper is part of the Symposium-in-Print: DNA Photodynamics.

*email: thomas.gustavsson@cea.fr (Thomas Gustavsson)

Abstract

We report a comparison of the steady-state absorption and fluorescence spectra of three representative uracil derivatives (uracil, thymine and 5-fluorouracil) in alcoholic solutions. The present results are compared with those from our previous experimental and computational studies of the same compounds in water and acetonitrile. The effects of solvent polarity and hydrogen bonding on the spectra are discussed in the light of theoretical predictions. This comparative analysis provides a more complete picture of the solvent effects on the absorption and fluorescence properties of pyrimidine nucleobases, with special emphasis on the mechanism of the excited state deactivation.

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