This paper is dedicated to Professor Margaret L. Kripke on the occasion of her retirement from the University of Texas MD Anderson Cancer Center.
p53 Tumor Suppressor Gene: A Critical Molecular Target for UV Induction and Prevention of Skin Cancer†
Article first published online: 23 OCT 2007
Photochemistry and Photobiology
Volume 84, Issue 1, pages 55–62, January/February 2008
How to Cite
Benjamin, C. L., Ullrich, S. E., Kripke, M. L. and Ananthaswamy, H. N. (2008), p53 Tumor Suppressor Gene: A Critical Molecular Target for UV Induction and Prevention of Skin Cancer. Photochemistry and Photobiology, 84: 55–62. doi: 10.1111/j.1751-1097.2007.00213.x
- Issue published online: 23 OCT 2007
- Article first published online: 23 OCT 2007
- Received 20 July 2007, accepted 22 August 2007
The relationship between exposure to UV radiation and development of skin cancer has been well established. Several studies have shown that UVB induces unique mutations (CT and CCTT transitions) in the p53 tumor suppressor gene that are not commonly induced by other carcinogens. Our studies have demonstrated that UV-induced mouse skin cancers contain p53 mutations at a high frequency and that these mutations can be detected in UV-irradiated mouse skin well before the appearance of skin tumors. This observation suggested that it might be possible to use p53 mutations as a biologic endpoint for testing the efficacy of sunscreens in photoprotection studies. Indeed, application of SPF 15 sunscreens to mouse skin before each UVB irradiation resulted in reduction in the number of p53 mutations. Because p53 mutations represent an early essential step in photocarcinogenesis, these results imply that inhibition of this event may protect against skin cancer development. This hypothesis was confirmed by our finding that sunscreens used in p53 mutation inhibition experiments also protected mice against UVB-induced skin cancer.