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References

  • 1
    Epstein, J. H. (1983) Photocarcinogenesis, skin cancer and aging. J. Am. Acad. Dermatol. 9, 487502.
  • 2
    Pathak, M. A. (1991) Ultraviolet radiation and the development of non-melanoma and melanoma skin cancer: Clinical and experimental evidence. Skin Pharmacol. 4(Suppl. 1), 8594.
  • 3
    Gilchrest, B. A. and G. S. Rogers (1993) Photoaging. In Clinical Photomedicine (Edited by H. W.Lim and N. A.Soter), pp. 95111. Marcel Dekker, Inc., New York.
  • 4
    Pathak, M. A., K. Jimbow and T. Fitzpatrick (1980) Photobiology of pigment cell. In Phenotypic Expression in Pigment Cells (Edited by M.Seiji), pp. 655670. University of Tokyo Press, Tokyo.
  • 5
    Hunt, G., S. Kyne, S. Ito, K. Wakamatsu, C. Todd and A. J. Thody (1995) Eumelanin and pheomelanin contents of human epidermis and cultured melanocytes. Pigment Cell Res. 8, 202208.
  • 6
    Hennessy, A., C. Oh, B. Diffey, K. Wakamatsu, S. Ito and J. Rees (2005) Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation. Pigment Cell Res. 18, 220223.
  • 7
    Wakamatsu, K., R. Kavanagh, A. L. Kadekaro, S. Terzieva, R. A. Strum, S. Leachman, Z. A. Abdel-malek and S. Ito (2006) Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin. Pigment Cell Res. 19, 154162.
  • 8
    Pathak, M. A. and T. B. Fitzpatrick (1974) The role of natural photoprotective agents in human skin. In Sunlight and Man (Edited by T. B.Fitzpatrick, M. A.Pathak, L. C.Haber, M.Seiji and A.Kukita), pp. 725750. University of Tokyo Press, Tokyo.
  • 9
    Kaidbey, K. H., P. Poh Agin, R. M. Sayre and A. M. Kligman (1979) Photoprotection by melanin—A comparison of black and Caucasian skin. J. Am. Acad. Dermatol. 1, 249260.
  • 10
    Sober, A. J., R. A. Lew, H. K. Koh and R. L. Barnhill (1991) Epidemiology of cutaneous melanoma. An update. Dermatol. Clin. 9, 617629.
  • 11
    Gilchrest, B. A., M. S. Eller, A. C. Geller and M. Yaar (1999) The pathogenesis of melanoma induced by ultraviolet radiation. N. Engl. J. Med. 340, 13411348.
  • 12
    MacLennan, R., A. C. Green, G. R. C. McLeod and N. G. Martin (1992) Increasing incidence of cutaneous melanoma in Queensland, Australia. J. Natl Cancer Inst. 84, 14271432.
  • 13
    Chedekel, M. R., S. K. Smith, P. W. Post, A. Pokora and D. L. Vessell (1978) Photodestruction of pheomelanin: Role of oxygen. Proc. Natl Acad. Sci. USA 75, 53955399.
  • 14
    Felix, C. C., J. S. Hyde, T. Sarna and R. C. Sealy (1978) Melanin photoreaction in aerated media: Electron spin resonance evidence of production of superoxide and hydrogen peroxide. Biochem. Biophys. Res. Commun. 84, 335341.
  • 15
    Szabo, G. (1969) Racial differences in the fate of melanosomes in human epidermis. Nature 222, 1081.
  • 16
    Pathak, M. A., Y. Hori, G. Szabo and T. B. Fitzpatrick (1971) The photobiology of melanin pigmentation in human skin. In Biology of Normal and Abnormal Melanocytes (Edited by T.Kawamura, T. B.Fitzpatrick and M.Seiji), pp. 149169. University Park Press, Baltimore, MD.
  • 17
    Kobayashi, N., A. Nakagawa, T. Muramatsu, Y. Yamashina, T. Shirai, M. W. Hashimoto, Y. Ishigaki, T. Ohnishi and T. Mori (1998) Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis. J. Invest. Dermatol. 110, 806810.
  • 18
    Bustamante, J., L. Bredeston, G. Malanga and J. Mordoh (1993) Role of melanin as a scavenger of active oxygen species. Pigment Cell Res. 6, 348353.
  • 19
    Geschwind, I. I., R. A. Huseby and R. Nishioka (1972) The effect of melanocyte-stimulating hormone on coat color in the mouse. Rec. Prog. Hormone Res. 28, 91130.
  • 20
    Quevedo, W. C., Jr, R. D. Fleischmann and T. J. Holstein (1981) Pheomelanogenesis in the mouse: A review of its genetic and developmental features. In Pigment Cell 1981: Phenotypic Expression in Pigment Cells (Edited by M.Seiji), pp. 129137. University of Tokyo Press, Tokyo.
  • 21
    Bultman, S. J., E. J. Michaud and R. P. Woychik (1992) Molecular characterization of the mouse agouti locus. Cell 71, 11951204.
  • 22
    Millar, S. E., M. W. Miller, M. E. Stevens and G. S. Barsh (1995) Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated. Development 121, 32233232.
  • 23
    Tamate, H. B. and T. Takeuchi (1984) Action of the e locus of mice in the response of phaeomelanic hair follicles to α-melanocyte-stimulating hormone in vitro. Science 224, 12411242.
  • 24
    Robbins, L. S., J. H. Nadeau, K. R. Johnson, M. A. Kelly, L. Roselli-Rehfuss, E. Baack, K. G. Mountjoy and R. D. Cone (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827834.
  • 25
    Lu, D., D. Willard, I. R. Patel, S. Kadwell, L. Overton, T. Kost, M. Luther, W. Chen, R. P. Woychik, W. O. Wilkison and R. D. Cone (1994) Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799802.
  • 26
    Miller, M. W., D. M. J. Duhl, H. Vrieling, S. P. Cordes, M. M. Ollmann, B. M. Winkes and G. S. Barsh (1993) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7, 454467.
  • 27
    Sakai, C., M. Ollmann, T. Kobayashi, Z. Abdel-Malek, J. Muller, W. D. Vieira, G. Imokawa, G. S. Barsh and V. J. Hearing (1997) Modulation of murine melanocyte function in vitro by agouti signal protein. EMBO J. 16, 35443552.
  • 28
    Prota, G. (1992) Melanins and Melanogenesis. Academic Press, Inc., San Diego.
  • 29
    Sawyer, T. K., V. J. Hruby, M. E. Hadley and M. H. Engel (1983) α-Melanocyte stimulating hormone: Chemical nature and mechanism of action. Am. Zool. 23, 529540.
  • 30
    Sherbrooke, W. C., M. E. Hadley and A. M. L. Castrucci (1988) Melanotropic peptides and receptors: An evolutionary perspective in vertebrate physiologic color change. In Melanotropic Peptides, Vol. II (Edited by M. E.Hadley), pp. 175190. CRC Press, Washington, DC.
  • 31
    Lerner, A. B. and J. S. McGuire (1964) Melanocyte-stimulating hormone and adrenocorticotrophic hormone. Their relation to pigmentation. N. Engl. J. Med. 270, 539546.
  • 32
    Levine, N., S. N. Sheftel, T. Eytan, R. T. Dorr, M. E. Hadley, J. C. Weinrach, G. A. Ertl, K. Toth and V. J. Hruby (1991) Induction of skin tanning by the subcutaneous administration of a potent synthetic melanotropin. JAMA 266, 27302736.
  • 33
    Mountjoy, K. G., L. S. Robbins, M. T. Mortrud and R. D. Cone (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257, 12481251.
  • 34
    Chhajlani, V., R. Muceniece and J. E. S. Wikberg (1993) Molecular cloning of a novel human melanocortin receptor. Biochem. Biophys. Res. Commun. 195, 866873.
  • 35
    Abdel-Malek, Z., V. B. Swope, I. Suzuki, C. Akcali, M. D. Harriger, S. T. Boyce, K. Urabe and V. J. Hearing (1995) Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc. Natl Acad. Sci. USA 92, 17891793.
  • 36
    Hunt, G., S. Kyne, K. Wakamatsu, S. Ito and A. J. Thody (1995) Nle4DPhe7α-melanocyte-stimulating hormone increases the eumelanin:phaeomelanin ratio in cultured human melanocytes. J. Invest. Dermatol. 104, 8385.
  • 37
    Suzuki, I., A. Tada, M. M. Ollmann, G. S. Barsh, S. Im, M. L. Lamoreux, V. J. Hearing, J. Nordlund and Z. A. Abdel-Malek (1997) Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to α-melanotropin. J. Invest. Dermatol. 108, 838842.
  • 38
    Chakraborty, A. K., Y. Funasaka, A. Slominski, G. Ermak, J. Hwang, J. M. Pawelek and M. Ichihashi (1996) Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by ultraviolet B. Biochim. Biophys. Acta 1313, 130138.
  • 39
    Wakamatsu, K., A. Graham, D. Cook and A. J. Thody (1997) Characterization of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res. 10, 288297.
  • 40
    Krude, H., H. Biebermann, W. Luck, R. Horn, G. Brabant and A. Gruters (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19, 155157.
  • 41
    Valverde, P., E. Healy, I. Jackson, J. L. Rees and A. J. Thody (1995) Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat. Genet. 11, 328330.
  • 42
    Box, N. F., J. R. Wyeth, L. E. O’Gorman, N. G. Martin and R. A. Sturm (1997) Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum. Mol. Genet. 6, 18911897.
  • 43
    Smith, R., E. Healy, S. Siddiqui, N. Flanagan, P. M. Steijlen, I. Rosdahl, J. P. Jacques, S. Rogers, R. Turner, I. J. Jackson, M. A. Birch-Machin and J. L. Rees (1998) Melanocortin 1 receptor variants in an Irish population. J. Invest. Dermatol. 111, 119122.
  • 44
    Scott, M. C., K. Wakamatsu, S. Ito, A. L. Kadekaro, N. Kobayashi, J. Groden, R. Kavanagh, T. Takakuwa, V. Virador, V. J. Hearing and Z. A. Abdel-Malek (2002) Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. J. Cell Sci. 115, 23492355.
  • 45
    Ringholm, A., J. Klovins, R. Rudzish, S. Phillips, J. L. Rees and H. B. Schioth (2004) Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair. J. Invest. Dermatol. 123, 917923.
  • 46
    Garcia-Borron, J. C., B. L. Sanchez-Laorden and C. Jimenez-Cervantes (2005) Melanocortin-1 receptor structure and functional regulation. Pigment Cell Res. 18, 393410.
  • 47
    Rana, B. K., D. Hewett-Emmett, L. Jin, B. H.-J. Chang, N. Sambuughin, M. Lin, S. Watkins, M. Bamshad, L. B. Jorde, M. Ramsay, T. Jenkins and W.-H. Li (1999) High polymorphism at the human melanocortin 1 receptor locus. Genetics 151, 15471557.
  • 48
    Suzuki, I., R. Cone, S. Im, J. Nordlund and Z. Abdel-Malek (1996) Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137, 16271633.
  • 49
    Abdel-Malek, Z., V. B. Swope, J. Pallas, K. Krug and J. J. Nordlund (1992) Mitogenic, melanogenic and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens. J. Cell. Physiol. 150, 416425.
  • 50
    Im, S., O. Moro, F. Peng, E. E. Medrano, J. Cornelius, G. Babcock, J. Nordlund and Z. Abdel-Malek (1998) Activation of the cyclic AMP pathway by α-melanotropin mediates the response of human melanocytes to ultraviolet B radiation. Cancer Res. 58, 4754.
  • 51
    Kupper, T. S., A. O. Chua, P. Flood, J. McGuire and U. Gubler (1987) Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J. Clin. Invest. 80, 430436.
  • 52
    Imokawa, G., Y. Yada and M. Miyagishi (1992) Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J. Biol. Chem. 267, 2467524680.
  • 53
    Halaban, R., S. Ghosh, P. Duray, J. M. Kirkwood and A. B. Lerner (1986) Human melanocytes cultured from nevi and melanomas. J. Invest. Dermatol. 87, 95101.
  • 54
    Halaban, R., R. Langdon, N. Birchall, C. Cuono, A. Baird, G. Scott, G. Moellmann and J. McGuire (1988) Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J. Cell Biol. 107, 16111619.
  • 55
    Barker, D., K. Dixon, E. E. Medrano, D. Smalara, S. Im, D. Mitchell, G. Babcock and Z. A. Abdel-Malek (1995) Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation. Cancer Res. 55, 40414046.
  • 56
    Kadekaro, A. L., R. Kavanagh, H. Kanto, S. Terzieva, J. Hauser, N. Kobayashi, S. Schwemberger, J. Cornelius, G. Babcock, H. G. Shertzer, G. Scott and Z. A. Abdel-Malek (2005) α-Melanocortin and endothelin-1 activate anti-apoptotic pathways and reduce DNA damage in human melanocytes. Cancer Res. 65, 42924299.
  • 57
    Hauser, J. E., A. L. Kadekaro, R. J. Kavanagh, K. Wakamatsu, S. Terzieva, S. Schwemberger, G. Babcock, M. B. Rao, S. Ito and Z. A. Abdel-Malek (2006) Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment Cell Res. 19, 303314.
  • 58
    McGill, G. G., M. Horstmann, H. R. Widlund, J. Du, G. Motyckova, E. K. Nishimura, Y.-L. Lin, S. Ramaswamy, W. Avery, H.-F. Ding, S. A. Jordan, I. J. Jackson, S. J. Korsmeyer, T. R. Golub and D. E. Fisher (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109, 707718.
  • 59
    Bohm, M., I. Wolff, T. E. Scholzen, S. J. Robinson, E. Healy, T. A. Luger, T. Schwarz and A. Schwarz (2005) alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J. Biol. Chem. 280, 57955802.
  • 60
    Eller, M. S., K. Ostrom and B. A. Gilchrest (1996) DNA damage enhances melanogenesis. Proc. Natl Acad. Sci. USA 93, 10871092.
  • 61
    Arad, S., N. Konnikov, D. A. Goukassian and B. A. Gilchrest (2006) T-oligos augment UV-induced protective responses in human skin. FASEB J. 20, 18951897.
  • 62
    Klein-Parker, H. A., L. Warshawski and V. A. Tron (1994) Melanocytes in human skin express bcl-2 protein. J. Cutan. Pathol. 21, 297301.
  • 63
    Plettenberg, A., C. Ballaun, J. Pammer, M. Mildner, D. Strunk, W. Weninger and E. Tschachler (1995) Human melanocytes and melanoma cells constitutively express the bcl-2 proto-oncogene in situ and in cell culture. Am. J. Pathol. 146, 651659.
  • 64
    Medrano, E. E., S. Im, F. Yang and Z. Abdel-Malek (1995) UVB light induces G1 arrest in human melanocytes by prolonged inhibition of pRb phosphorylation associated with long term expression of the protein p21Waf−1/SDI/Cip−1 protein. Cancer Res. 55, 40474052.
  • 65
    Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein and R. W. Craig (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 63046311.
  • 66
    Smith, M. L., I.-T. Chen, Q. Zhan, P. M. O’Connor and A. J. Fornace Jr (1995) Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 10, 10531059.
  • 67
    Khlgatian, M. K., I. M. Hadshiew, P. Asawanonda, M. Yaar, M. S. Eller, M. Fujita, D. A. Norris and B. A. Gilchrest (2002) Tyrosinase gene expression is regulated by p53. J. Invest. Dermatol. 118, 126132.
  • 68
    Cui, R., H. R. Widlund, E. Feige, J. Y. Lin, D. L. Wilensky, V. E. Igras, J. D’Orazio, C. Y. Fung, C. F. Schanbacher, S. R. Granter and D. E. Fisher (2007) Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell 128, 853864.
  • 69
    Corre, S., A. Primot, E. Sviderskaya, D. C. Bennett, S. Vaulont, C. R. Goding and M. D. Galibert (2004) UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1). J. Biol. Chem. 279, 5122651233.
  • 70
    Scott, M. C., I. Suzuki and Z. A. Abdel-Malek (2002) Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors, and by UV radiation. Pigment Cell Res. 15, 433439.
  • 71
    Swope, V. B., E. E. Medrano, D. Smalara and Z. Abdel-Malek (1995) Long-term proliferation of human melanocytes is supported by the physiologic mitogens α-melanotropin, endothelin-1, and basic fibroblast growth factor. Exp. Cell Res. 217, 453459.
  • 72
    Tada, A., I. Suzuki, S. Im, M. B. Davis, J. Cornelius, G. Babcock, J. J. Nordlund and Z. A. Abdel-Malek (1998) Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. Cell Growth Differ. 9, 575584.
  • 73
    Kanetsky, P. A., J. Swoyer, S. Panossian, R. Holmes, D. Guerry and T. R. Rebbeck (2002) A polymorphism in the agouti signaling protein gene is associated with human pigmentation. Am. J. Hum. Genet. 70, 770775.
  • 74
    Halder, R. M. and S. Bridgeman-Shah (1995) Skin cancer in African Americans. Cancer 75, 667673.
  • 75
    Palmer, J. S., D. L. Duffy, N. F. Box, J. F. Aitken, L. E. O’Gorman, A. C. Green, N. K. Hayward, N. G. Martin and R. A. Sturm (2000) Melanocortin-1 receptor polymorphisms and risk of melanoma: Is the association explained solely by pigmentation phenotype? Am. J. Hum. Genet. 66, 176186.
  • 76
    Kennedy, C., J. Ter Huurne, M. Berkhout, N. Gruis, M. Bastiaens, W. Bergman, R. Willemze and J. N. Bouwes Bavinck (2001) Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color. J. Invest. Dermatol. 117, 294300.
  • 77
    Landi, M. T., P. A. Kanetsky, S. Tsang, B. Gold, D. Munroe, T. Rebbeck, J. Swoyer, M. Ter-Minassian, M. Hedayati, L. Grossman, A. M. Goldstein, D. Calista and R. M. Pfeiffer (2005) MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population. J. Natl Cancer Inst. 97, 9981007.
  • 78
    Box, N. F., D. L. Duffy, W. Chen, M. Stark, N. G. Martin, R. A. Sturm and N. K. Hayward (2001) MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am. J. Hum. Genet. 69, 765773.
  • 79
    Stratigos, A. J., G. Dimisianos, V. Nikolaou, M. Poulou, V. Sypsa, I. Stefanaki, O. Papadopoulos, D. Polydorou, M. Plaka, E. Christofidou, H. Gogas, D. Tsoutsos, O. Kastana, C. Antoniou, A. Hatzakis, E. Kanavakis and A. D. Katsambas (2006) Melanocortin receptor-1 gene polymorphisms and the risk of cutaneous melanoma in a low-risk southern European population. J. Invest. Dermatol. 126, 18421849.
  • 80
    Tadokoro, T., N. Kobayashi, B. Z. Zmudzka, S. Ito, K. Wakamatsu, Y. Yamaguchi, K. S. Korossy, S. A. Miller, J. Z. Beer and V. J. Hearing (2003) UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. FASEB J. 17, 11771179.
  • 81
    Ziegler, A., A. S. Jonason, D. J. Leffell, J. A. Simon, H. W. Sharma, J. Kimmelman, L. Remington, T. Jacks and D. E. Brash (1994) Sunburn and p53 in the onset of skin cancer. Nature 372, 773776.
  • 82
    Lubbe, J., M. Reichel, G. Burg and P. Kleihues (1994) Absence of p53 gene mutations in cutaneous melanoma. J. Invest. Dermatol. 102, 819821.
  • 83
    Papp, T., M. Jafari and D. Schiffmann (1996) Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesions. J. Cancer Res. Clin. Oncol. 122, 541548.
  • 84
    Wei, Q., J. E. Lee, J. E. Gershenwald, M. I. Ross, P. F. Mansfield, S. S. Strom, L. E. Wang, Z. Guo, Y. Qiao, C. I. Amos, M. R. Spitz and M. Duvic (2003) Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J. Natl Cancer Inst. 95, 308315.
  • 85
    Sarkar-Agrawal, P., I. Vergilis, N. E. Sharpless, R. A. DePinho and T. M. Runger (2004) Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. J. Natl Cancer Inst. 96, 17901793.
  • 86
    Davies, H., G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzles, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton and P. A. Futreal (2002) Mutations of the BRAF gene in human cancer. Nature 417, 949954.
  • 87
    Landi, M. T., J. Bauer, R. M. Pfeiffer, D. E. Elder, B. Hulley, P. Minghetti, D. Calista, P. A. Kanetsky, D. Pinkel and B. C. Bastian (2006) MC1R germline variants confer risk for BRAF-mutant melanoma. Science 313, 521522.
  • 88
    Abdel-Malek, Z. A., A. L. Kadekaro, R. J. Kavanagh, A. Todorovic, L. N. Koikov, J. C. McNulty, P. J. Jackson, G. L. Milhauser, S. Schwemberger, G. Babcock, C. Haskell-Luevano and J. J. Knittel (2006) Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced damage and cytotoxicity. FASEB J. 20, 15611563.