Photosensitized DNA Damage: The Case of Fluoroquinolones

Authors


  • This invited paper is part of a Symposium-in-Print on Pharmaceutical Photochemistry.

*Corresponding author email: mmiranda@qim.upv.es (Miguel Angel Miranda)

Abstract

This review focuses on DNA damage photosensitized by the fluoroquinolone (FQ) antibacterial drugs. The in vivo evidence for photocarcinogenesis mediated by FQs is presented in the introduction. The different methods employed for detection of DNA-photodamage mediated by FQs are then summarized, including gel electrophoresis (with whole cells, with isolated DNA and with oligonucleotides) and chromatographic analysis (especially HPLC with electrochemical and MS/MS detection). The chemical mechanisms involved in the formation of the reported lesions are discussed on the basis of product studies and transient spectroscopic evidence. In general, the literature coverage is limited to the last decade, although some earlier citations are also included.

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