Photophysics of Zinc (II) Phthalocyanine Polymer and Gel Formulation

Authors

  • Myriam E. Rodriguez,

    1. INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Fisica, Facultad de Ciencias   Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    2. Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires,   Buenos Aires, Argentina
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    • §

      Current address: Myriam E. Rodriguez, Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA

  • Virginia E. Diz,

    1. INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Fisica, Facultad de Ciencias   Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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  • Josefina Awruch,

    1. Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires,   Buenos Aires, Argentina
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  • Lelia E. Dicelio

    Corresponding author
    1. INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Fisica, Facultad de Ciencias   Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Corresponding author email: led@qi.fcen.uba.ar (Lelia E. Dicelio)

Abstract

The photophysical properties of lipophilic phthalocyanines encapsulated into a polymer and two different gels were studied in order to predict their photosensitizing efficacy in vivo. Photophysical techniques for solid phase were adapted for light dispersing samples. Gel formulation of two tetrasubstituted phthalocyanines, tetra-t-butylphthalocyaninato zinc(II) (1), tetrakis(1,1-dimethyl-2-phthalimido)ethylphtalocyaninatozinc(II) (2) and two octasubstituted phthalocyanines, 2,3,9,10,16,17,23,24-octakis(decyloxy)phthalocyaninatozinc(II) (3) and 2,3,9,10,16,17,23,24-octakis[(N,N-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (4) were investigated for their possible use in photodynamic therapy for topical purposes. Supporting the fact that gel formulation improves the photophysical properties of phthalocyanines, singlet molecular oxygen quantum yield (ΦΔ) values for 14 zinc(II) phthalocyaninates in Lutrol® F 127-Cremophor® RH 40 were 0.60, 0.60, 0.20 and 0.26, respectively. Permeation studies showed that no release of phthalocyanines occurs, thus indicating there should be no risk of generalized skin photosensitivity in areas other than the dye-deposition site.

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