TiO2 Nanotubes as a Therapeutic Agent for Cancer Thermotherapy

  1. Chongmu Lee1,*,
  2. Chanseok Hong1,
  3. Hohyeong Kim1,
  4. Jungwoo Kang1,
  5. Hong Mei Zheng2

Article first published online: 16 APR 2010

DOI: 10.1111/j.1751-1097.2010.00731.x

Issue

Photochemistry and Photobiology

Photochemistry and Photobiology

Special Issue: Symposium in Print: "Phototoxicity of the Skin and Eye" in honor of Dr Colin Chignell

Volume 86, Issue 4, pages 981–989, July/August 2010

Additional Information

How to Cite

Lee, C., Hong, C., Kim, H., Kang, J. and Zheng, H. M. (2010), TiO2 Nanotubes as a Therapeutic Agent for Cancer Thermotherapy. Photochemistry and Photobiology, 86: 981–989. doi: 10.1111/j.1751-1097.2010.00731.x

Author Information

  1. 1

    Department of Materials Science and Engineering, Inha University, Incheon, Korea

  2. 2

    Department of Biomedical Sciences and Internal Medicine, College of Medicine, Inha University, Incheon, Korea

* Corresponding author email: cmlee@inha.ac.kr (Chongmu Lee)

Publication History

  1. Issue published online: 7 JUL 2010
  2. Article first published online: 16 APR 2010
  3. Received 1 November 2009, accepted 22 February 2010

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Abstract

We report the photothermal properties as well as the in vitro cell test results of titanium oxide nanotubes (TiO2 NTs) as a potential therapeutic agent for cancer thermotherapy in combination with near-infrared (NIR) light. TiO2 NTs are found to have a higher photothermal effect upon exposure to NIR laser than Au nanoparticles and single-wall carbon nanotubes, which have also attracted considerable interest as therapeutic agents for cancer thermotherapy. The temperature increase of a TiO2 NT/NaCl suspension during NIR laser exposure is larger than that of a TiO2 NT/D.I. water suspension due to the heat generated by the formation of Na2TiF6. According to the in vitro cell test results the cells exposed to NIR laser without TiO2 NT treatment have a cell viability of 96.4%. Likewise, the cells treated with TiO2 NTs but not with NIR irradiation also have a cell viability of 98.2%. Combination of these two techniques, however, shows a cell viability of 1.35%. Also, the cell deaths are mostly due to necrosis but partly due to late apoptosis. These results suggest that TiO2 NTs can be used effectively as therapeutic agents for cancer thermotherapy due to their excellent photothermal properties and high biocompatibility.

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