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Infrared (810 nm) Low-Level Laser Therapy in Experimental Model of Strain-Induced Skeletal Muscle Injury in Rats: Effects on Functional Outcomes

Authors

  • Luciano Ramos,

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
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  • Ernesto Cesar Pinto Leal Junior,

    1. Post Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, SP, Brazil
    2. Post Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, São Paulo, SP, Brazil
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  • Rodney Capp Pallotta,

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
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  • Lucio Frigo,

    1. Biological Sciences and Health Center, Cruzeiro do Sul University, São Paulo, SP, Brazil
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  • Rodrigo Labat Marcos,

    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
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  • Maria Helena Catelli de Carvalho,

    1. Laboratory of Cardiovascular Pharmacology, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
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  • Jan Magnus Bjordal,

    1. Centre for Evidence-Based Practice, Bergen University College, Bergen, Norway
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  • Rodrigo Álvaro Brandão Lopes-Martins

    Corresponding author
    1. Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
    2. Post Graduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, SP, Brazil
    3. Post Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, São Paulo, SP, Brazil
      Corresponding author email: rmartins@icb.usp.br (Rodrigo Álvaro Brandão Lopes-Martins)
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Corresponding author email: rmartins@icb.usp.br (Rodrigo Álvaro Brandão Lopes-Martins)

Abstract

Muscle strains are among the most prevalent causes for athletes’ absence from sport activities. Low-level laser therapy (LLLT) has recently emerged as a potential contender to nonsteroidal anti-inflammatory drugs in muscle strain treatment. In this work we investigated effects of LLLT and diclofenac on functional outcomes in the acute stage after muscle strain injury in rats. Muscle strain was induced by overloading the tibialis anterior muscle of rats during anesthesia. The injured groups received either no treatment, or a single treatment with diclofenac 30 min prior to injury, or LLLT (810 nm, 100 mW) with doses of 1, 3, 6 or 9 J, at 1 h after injury. Functional outcome measures included a walking index and assessment of electrically induced muscle performance. All treatments (except 9 J LLLT) significantly improved the walking index 12 h postinjury compared with the untreated group. The 3 J group also showed a significantly better walking index than the drug group. All treatments significantly improved muscle performance at 6 and 12 h. LLLT dose of 3 J was as effective as the pharmacological agent in improving functional outcomes in the early phase after a muscle strain injury in rats.

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