This paper is part of the Special Issue in Commemoration of the 70th birthday of Dr. David R. Bickers.
The Circadian Control of Skin and Cutaneous Photodamage†
Article first published online: 21 FEB 2012
© 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology
Photochemistry and Photobiology
Volume 88, Issue 5, pages 1037–1047, September/October 2012
How to Cite
Desotelle, J. A., Wilking, M. J. and Ahmad, N. (2012), The Circadian Control of Skin and Cutaneous Photodamage. Photochemistry and Photobiology, 88: 1037–1047. doi: 10.1111/j.1751-1097.2012.01099.x
- Issue published online: 5 SEP 2012
- Article first published online: 21 FEB 2012
- Accepted manuscript online: 25 JAN 2012 12:40PM EST
- Received 10 November 2011, accepted 16 January 2012
Biologically, light including ultraviolet (UV) radiation is vital for life. However, UV exposure does not come without risk, as it is a major factor in the development of skin cancer. Natural protections against UV damage may have been affected by lifestyle changes over the past century, including changes in our sun exposure due to working environments, and the use of sunscreens. In addition, extended “day time” through the use of artificial light may contribute to the disruption of our circadian rhythms; the daily cycles of changes in critical bio-factors including gene expression. Circadian disruption has been implicated in many health conditions, including cardiovascular, metabolic and psychiatric diseases, as well as many cancers. Interestingly, the pineal hormone melatonin plays a role in both circadian regulation as well as protection from UV skin damage, and is therefore an important factor to consider when studying the impact of UV light. This review discusses the beneficial and deleterious effects of solar exposure, including UV skin damage, Vitamin D production, circadian rhythm disruption and the impact of melatonin. Understanding these benefits and risks is critical for the development of protective strategies against solar radiation.