Equally contributing senior authors.
Expression and Function of Macrophage Migration Inhibitory Factor in the Pathogenesis of UV-Induced Cutaneous Nonmelanoma Skin Cancer†
Article first published online: 8 MAR 2012
© 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology
Photochemistry and Photobiology
Volume 88, Issue 5, pages 1157–1164, September/October 2012
How to Cite
Heise, R., Vetter-Kauczok, C. S., Skazik, C., Czaja, K., Marquardt, Y., Lue, H., Merk, H. F., Bernhagen, J. and Baron, J. M. (2012), Expression and Function of Macrophage Migration Inhibitory Factor in the Pathogenesis of UV-Induced Cutaneous Nonmelanoma Skin Cancer. Photochemistry and Photobiology, 88: 1157–1164. doi: 10.1111/j.1751-1097.2012.01108.x
This paper is part of the Special Issue in Commemoration of the 70th birthday of Dr. David R. Bickers.
- Issue published online: 5 SEP 2012
- Article first published online: 8 MAR 2012
- Accepted manuscript online: 11 FEB 2012 10:19AM EST
- Received 16 November 2011, accepted 6 February 2012
Figure S1. UVB irradiation with 50 mJ cm−2 did not lead to apoptosis in keratinocytes. NHEK were exposed to a single dose of 50 or 100 mJ UVB cm−2, while control cells remained untreated. Cells were incubated with FITC-annexin V in a buffer containing propidium iodide (PI) and analyzed by measuring the fluorescence intensity using flow cytometry.
Figure S2. Expression of the CD74 MIF receptor is not upregulated by UVB light. NHEK and HaCaT cells were exposed to a single does of 50 mJ cm−2. Control cells remained untreated. Analysis of CD74 surface expression was performed 24 h after irradiation by FACS analysis using a receptor-specific FITC-labelled anti-CD74 antibody.
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