• 1
    Ris, H. B., H. J. Altermatt, B. Nachbur, C. M. Stewart, Q. Wang, C. K. Lim, R. Bonnett and U. Althaus (1996) Intraoperative photodynamic therapy with m-tetrahydroxyphenylchlorin for chest malignancies. Lasers Surg. Med. 18, 3945.
  • 2
    Ris, H. B., A. Giger, V. I. Hof, D. Mettler, J. C. Stewart, U. Althaus and H. J. Altermatt (1997) Experimental assessment of photodynamic therapy with chlorins for malignant mesothelioma. Eur. J. Cardiothorac. Surg. 12, 542548.
  • 3
    Betz, C. S., H. R. Jager, J. A. Brookes, R. Richards, A. Leunig and C. Hopper (2007) Interstitial photodynamic therapy for a symptom-targeted treatment of complex vascular malformations in the head and neck region. Lasers Surg. Med. 39, 571582.
  • 4
    Lou, P. J., H. R. Jager, L. Jones, T. Theodossy, S. G. Bown and C. Hopper (2004) Interstitial photodynamic therapy as salvage treatment for recurrent head and neck cancer. Br. J. Cancer 91, 441446.
  • 5
    Nyst, H. J., I. B. Tan, F. A. Stewart and A. J. Balm (2009) Is photodynamic therapy a good alternative to surgery and radiotherapy in the treatment of head and neck cancer? Photodiagn. Photodyn. Ther. 6, 311.
  • 6
    Chang, S. C., G. Buonaccorsi, A. MacRobert and S. G. Bown (1996) Interstitial and transurethral photodynamic therapy of the canine prostate using meso-tetra-(m-hydroxyphenyl) chlorin. Int. J. Cancer 67, 555562.
  • 7
    Chang, S. C., I. F. Chern and Y. H. Hsu (1999) Biological responses of dog prostate and adjacent structures after meso-tetra-(m-hydroxyphenyl) chlorin and aluminum disulfonated phthalocyanine based photodynamic therapy. Proc. Natl. Sci. Counc. Repub. China B 23, 158166.
  • 8
    Huang, Z., Q. Chen, D. Luck, J. Beckers, B. C. Wilson, N. Trncic, S. M. Larue, D. Blanc and F. W. Hetzel (2005) Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer. Lasers Surg. Med. 36, 390397.
  • 9
    Moore, C. M., T. R. Nathan, W. R. Lees, C. A. Mosse, A. Freeman, M. Emberton and S. G. Bown (2006) Photodynamic therapy using meso tetra hydroxy phenyl chlorin (mTHPC) in early prostate cancer. Lasers Surg. Med. 38, 356363.
  • 10
    Kubler, A. C., W. Stenzel, M. Ruhling, B. Meul and J. H. Fischer (2003) Experimental evaluation of possible side effects of intra-operative photodynamic therapy on rabbit blood vessels and nerves. Lasers Surg. Med. 33, 247255.
  • 11
    Wright, K. E., E. Liniker, M. Loizidou, C. Moore, A. J. Macrobert and J. B. Phillips (2009) Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model. Br. J. Cancer 101, 658665.
  • 12
    East, E. and J. B. Phillips (2008) Tissue engineered cell culture models for nervous system research. In Tissue Engineering Research Trends (Edited by G. N. Greco), pp. 141160. Nova Science Publishers, New York.
  • 13
    Gonzalez-Zulueta, M., L. M. Ensz, G. Mukhina, R. M. Lebovitz, R. M. Zwacka, J. F. Engelhardt, L. W. Oberley, V. L. Dawson and T. M. Dawson (1998) Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity. J. Neurosci. 18, 20402055.
  • 14
    Gegg, M. E., J. B. Clark and S. J. Heales (2005) Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity. Brain Res. 1036, 16.
  • 15
    Watts, L. T., M. L. Rathinam, S. Schenker and G. I. Henderson (2005) Astrocytes protect neurons from ethanol-induced oxidative stress and apoptotic death. J. Neurosci. Res. 80, 655666.
  • 16
    Rothstein, J. D., L. A. Bristol, B. Hosler, R. H. Brown, Jr and R. W. Kuncl (1994) Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proc. Natl Acad. Sci. U S A 91, 41554159.
  • 17
    Iwasaki, Y., K. Ikeda, T. Shiojima, N. Tagaya, T. Kobayashi and M. Kinoshita (1997) Bromocriptine prevents neuron damage following inhibition of superoxide dismutase in cultured ventral spinal cord neurons. Neurol. Res. 19, 389392.
  • 18
    Kimani, S. G., J. B. Phillips, J. I. Bruce, A. J. MacRobert and J. P. Golding (2012) Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy. Photochem. Photobiol. 88, 175187.
  • 19
    Ginsburg, I., S. Yedgar and J. Varani (1997) Diethyldithiocarbamate and nitric oxide synergize with oxidants and with membrane-damaging agents to injure mammalian cells. Free Radic. Res. 27, 143164.
  • 20
    Tanioka, H., T. Mizushima, A. Shirahige, K. Matsushita, K. Ochi, M. Ichimura, N. Matsumura, T. Shinji, M. Tanimoto and N. Koide (2006) Xanthine oxidase-derived free radicals directly activate rat pancreatic stellate cells. J. Gastroenterol. Hepatol. 21, 537544.
  • 21
    Han, Y. H., H. J. Moon, B. R. You, S. Z. Kim, S. H. Kim and W. H. Park (2009) The effects of buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on propyl gallate-treated HeLa cells in relation to cell growth, reactive oxygen species and glutathione. Int. J. Mol. Med. 24, 261268.
  • 22
    Golab, J., D. Nowis, M. Skrzycki, H. Czeczot, A. Baranczyk-Kuzma, G. M. Wilczynski, M. Makowski, P. Mroz, K. Kozar, R. Kaminski, A. Jalili, M. Kopec, T. Grzela and M. Jakobisiak (2003) Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J. Biol. Chem. 278, 407414.
  • 23
    Griffith, O. W. (1999) Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic. Biol. Med. 27, 922935.
  • 24
    Hamilton, D., J. H. Wu and G. Batist (2007) Structure-based identification of novel human gamma-glutamylcysteine synthetase inhibitors. Mol. Pharmacol. 71, 11401147.
  • 25
    Du, J., H. Suzuki, F. Nagase, A. A. Akhand, X. Y. Ma, T. Yokoyama, T. Miyata and I. Nakashima (2001) Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process. Free Radic. Biol. Med. 31, 469478.
  • 26
    Miller, R. L., G. Y. Sun and A. Y. Sun (2007) Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. Brain Res. 1167, 129139.
  • 27
    Roychowdhury, S., A. Luthe, G. Keilhoff, G. Wolf and T. F. Horn (2002) Oxidative stress in glial cultures: detection by DAF-2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxide. Glia 38, 103114.
  • 28
    Lobanov, A. V. and A. B. Uzdensky (2005) PDT-induced death of sensory neurons and glial cells in the isolated crayfish stretch receptor after proteolytic treatment. J. Neurosci. Res. 82, 866874.
  • 29
    Mytilineou, C., E. T. Kokotos Leonardi, B. C. Kramer, T. Jamindar and C. W. Olanow (1999) Glial cells mediate toxicity in glutathione-depleted mesencephalic cultures. J. Neurochem. 73, 112119.
  • 30
    de Bernardo, S., S. Canals, M. J. Casarejos, R. M. Solano, J. Menendez and M. A. Mena (2004) Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures. J. Neurochem. 91, 667682.
  • 31
    Koechli, O. R., G. N. Schaer, V. Schenk, U. Haller and H. Walt (1995) Assessment of effect of photosensitizers on cytotoxicity of photodynamic therapy in human breast cancer cell cultures. Arch. Gynecol. Obstet. 256, 167176.
  • 32
    Wang, Y., M. Qiao, J. J. Mieyal, L. M. Asmis and R. Asmis (2006) Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. Free Radic. Biol. Med. 41, 775785.
  • 33
    Aquilano, K., S. Baldelli, S. Cardaci, G. Rotilio and M. R. Ciriolo (2011) Nitric oxide is the primary mediator of cytotoxicity induced by GSH depletion in neuronal cells. J. Cell Sci. 124, 10431054.
  • 34
    Mizuno, K., T. Kume, C. Muto, Y. Takada-Takatori, Y. Izumi, H. Sugimoto and A. Akaike (2011) Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. J. Pharmacol. Sci. 115, 320328.
  • 35
    Vincent, A. M., K. Kato, L. L. McLean, M. E. Soules and E. L. Feldman (2009) Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms. Antioxid. Redox Signal. 11, 425438.
  • 36
    Fischer, L. R. and J. D. Glass (2010) Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures. Acta Neuropathol. 119, 249259.
  • 37
    Ghosh, N., R. Ghosh and S. C. Mandal (2011) Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease. Free Radic. Res. 45, 888905.
  • 38
    Vincent, A. M., J. W. Russell, K. A. Sullivan, C. Backus, J. M. Hayes, L. L. McLean and E. L. Feldman (2007) SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy. Exp. Neurol. 208, 216227.