• 1
    Moore, E. E., F. A. Moore, R. J. Franciose, F. J. Kim, W. L. Biffl and A. Banerjee (1994) The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. J. Trauma 37, 881887.
  • 2
    Simpson, R., R. Alon, L. Kobzik, C. R. Valeri, D. Shepro and H. B. Hechtman (1993) Neutrophil and non neutrophil-mediated injury in intestinal ischemia-reperfusion. Ann. Surg. 218, 444453.
  • 3
    Marcus, B. C., K. L. Hynes and B. L. Gewertz (1997) Loss of endothelial barrier function requires neutrophil adhesion. Surgery 122, 420426.
  • 4
    McCord, J. M. (1985) Oxygen-derived free radicals in postischaemic tissue injury. N. Engl. J. Med. 15, 9163.
  • 5
    Song, P. and M. H. Zou (2012) Regulation of NADPH oxidases by AMPK in cardiovascular systems. Free Radic. Biol. Med. 52, 16071619.
  • 6
    Aubert, J., K. Begriche, L. Knockaert, M. A. Robin and B. Fromenty (2011) Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role. Clin. Res. Hepatol. Gastroenterol. 35, 630637.
  • 7
    Victor, V. M., M. Rocha, R. Herance and A. Hernandez-Mijares (2011) Oxidative stress and mitochondrial dysfunction in type 2 diabetes. Curr. Pharm. Des. 17, 39473958.
  • 8
    Ghouleh, I., N. K. Khoo, U. G. Knaus, K. K. Griendling, R. M. Touyz, V. J. Thannickal, A. Barchowsky, W. M. Nauseef, E. E. Kelley, P. M. Bauer, V. Darley-Usmar, S. Shiva, E. Cifuentes-Pagano, B. A. Freeman, M. T. Gladwin and P. J. Pagano (2011) Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling. Free Radic. Biol. Med. 51, 12711288.
  • 9
    Xiang, M. and J. Fan (2010) Association of Toll-like receptor signaling and reactive oxygen species: A potential therapeutic target for posttrauma acute lung injury. Mediators Inflamm. 2010, 18.
  • 10
    Kota, B. P., T. H. Huang and B. D. Roufogalis (2005) An overview on biological mechanisms of PPARs. Pharmacol. Res. 51, 8594.
  • 11
    Simon, D. M., M. C. Arikan, S. Srisuma, S. Bhattacharya, L. W Tsai, E. P. Ingenito, F. Gonzalez, S. D. Shapiro and T. J. Mariani (2006) Epithelial cell PPARy contributes to normal lung maturation. FASEB J. 20, 15071509.
  • 12
    Belvisi, M. G., D. J. Hele and M. A. Birrell (2006) Peroxisome proliferator activated receptor-y agonists as therapy for chronic airway inflammation. Eur. J. Pharmacol. 533, 101109.
  • 13
    Denning, G. M. and Stoll, L. L. (2006) Peroxisome proliferator-activated receptors: Potential therapeutic targets in lung disease? Pediatr. Pulmonol. 41, 2334.
  • 14
    Benayoun, L., S. Letuve, A. Druilhe, J. Boczkowski, M. C. Dombret, P. Mechighel, J. Megret, G. Leseche, M. Aubier and M. Pretolani (2001) Regulation of peroxisome proliferator-activated receptor-y expression in human asthmatic airways: Relationship with proliferation, apoptosis, and airway remodeling. Am. J. Respir. Crit. Care Med. 164, 14871494.
  • 15
    Woerly, G., K. Honda, M. Loyens, J. P. Papin, J. Auwerx, B. Staels, M. Capron and D. Dombrowicz (2003) Peroxisome proliferator-activated receptors-α and y down-regulate allergic inflammation and eosinophil activation. J. Exp. Med. 198, 411421.
  • 16
    Lee, K. S., S. J. Park, S. R. Kim, K. H Min, S. M. Jin, H. K. Lee and Y. C. Lee (2006) Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor-y in a murine model of toluene diisocyanate-induced asthma. J. Immunol. 177, 52485257.
  • 17
    Aschkenasy, G., Z. Bromberg, N. Raj, C. S. Deutschman and Y. G. Weiss (2011) Enhanced Hsp70 expression protects against acute lung injury by modulating apoptotic pathways. PLoS ONE 6, 2695626962.
  • 18
    Namba, T., K. Tanaka, T. Hoshino, A. Azuma and T. Mizushima (2011) Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS ONE 6, 2729627304.
  • 19
    Wheeler, S. and H. R. Wong (2007) Heat shock response and acute lung injury. Free. Radic. Biol. Med. 42(1), 114.
  • 20
    Fernandes, T. R., V. Pontieri, A. Moretti, D. O Teixeira, F. Abatepaulo, F. G. Soriano, E. M. Negri, I. T. Velasco and H. P. Souza (2007) Hypertonic saline solution increases the expression of heat shock protein 70 and improves lung inflammation early after reperfusion in a rodent model of controlled hemorrhage. Shock 27, 172178.
  • 21
    Guiqi, G. (2011) Pre-treatment with glutamine attenuates lung injury in rats subjected to intestinal ischaemia-reperfusion. Injury 42, 7277.
  • 22
    Pires, D., M. Xavier, T. Araújo, J. A. Silva, F. Aimbire and R. Albertini (2011) Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat. Lasers Med. Sci. 26, 8594.
  • 23
    Chow, R. T., M. I. Johnson, R. A. Lopes-Martins and J. M. Bjordal (2009) Efficacy of low-level laser therapy in the management of neck pain: A systematic review and meta-analysis of randomized placebo or active-treatment controlled trials. Lancet 374, 18971908.
  • 24
    Bjordal, J. M., M. I. Johnson, V. Iversen, F. Aimbire and R. A. Lopes-Martins (2006) Low-level laser therapy in acute pain: A systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed. Laser Surg. 24, 158168.
  • 25
    Lampl, Y., J. A. Zivin, M. Fisher, R. Lew, L. Welin, B. Dahlof, P. Borenstein, B. Andersson, J. Perez, C. Caparo, S. Ilic and U. Oron (2007) Infrared laser therapy for ischemic stroke: A new treatment strategy: Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke 38, 18431849.
  • 26
    Kashanskaia, E. P. and A. A Fedorov (2009) Low-intensity laser radiation in the combined treatment of patients with chronic obstructive bronchitis. Vopr. Kurortol. Fizioter. Lech. Fiz. Kult. 2, 1922.
  • 27
    Nedeljković, M., R. Ljustina-Pribić and K. Savić (2008) Innovative approach to laser acupuncture therapy of acute obstruction in asthmatic children. Med. Pregl. 61, 123130.
  • 28
    Faradzheva, N. A. (2007) Efficiency of a combination of haloaerosols and helium-neon laser in the multimodality treatment of patients with bronchial asthma. Probl. Tuberk. Bolezn Legk 8, 5053.
  • 29
    de Lima, F. M., L. M. Moreira, A. B. Villaverde, R. Albertini, H. C. Castro-Faria-Neto and F. Aimbire (2011) Low-level laser therapy (LLLT) acts as cAMP-elevating agent in acute respiratory distress syndrome. Lasers Med. Sci. 26, 389400.
  • 30
    de Lima, F. M., A. B. Villaverde, R. Albertini, A. P de Oliveira, H. C. Faria Neto and F. Aimbire (2010) Low-level laser therapy associated to N-acetylcysteine lowers macrophage inflammatory protein-2 (MIP-2) mRNA expression and generation of intracellular reactive oxygen species in alveolar macrophages. Photomed. Laser Surg. 28, 763771.
  • 31
    Mafra de Lima, F., A. B. Villaverde, M. A. Salgado, H. C. Castro-Faria-Neto, E. Munin, R. Albertini and F. Aimbire (2010) Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat. J. Photochem. Photobiol., B 101, 271278.
  • 32
    de Lima, F. M., A. B. Villaverde, R. Albertini, J. C. Corrêa, R. L. Carvalho, E. Munin, T. Araújo, J. A. Silva and F. Aimbire (2011) Dual Effect of low-level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: Action on anti- and pro-inflammatory cytokines. Lasers Surg. Med. 43, 410420.
  • 33
    Bertolucci, L. E. and T. Grey (1995) Clinical analysis of mid-laser versus placebo treatment of arthralgic TMJ degenerative joints. Cranio 13, 2629.
  • 34
    Bjordal, J. M., M. I. Johnson, V. Iversen, F. Aimbire and R. A. Lopes-Martins (2006) Low-level laser therapy in acute pain: A systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed. Laser Surg. 24, 158168.
  • 35
    Caetano, K. S., M. A Frade, D. G. Minatel, L. A. Santana and C. S. Enwemeka (2009) Phototherapy improves healing of chronic venous ulcers. Photomed. Laser Surg. 27, 111118.
  • 36
    Basford, J. R., C. G. Sheffield and W. S. Harmsen (1999) Laser therapy: A randomized, controlled trial of the effects of low-intensity Nd:YAG laser irradiation on musculoskeletal back pain. Arch. Phys. Med. Rehabil. 80, 647652.
  • 37
    Leal Junior, E. C., R. A. Lopes-Martins, A. A. Vanin, B. M. Baroni, D. Grosselli, T. De Marchi, V. V. Iversen and J. M. Bjordal (2009) Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans. Lasers Med. Sci. 24, 425431.
  • 38
    Rochkind, S., L. Leider-Trejo, M. Nissan, M. H. Shamir, O. Kharenko and M. Alon (2007) Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study). Photomed. Laser Surg. 25, 137143.
  • 39
    Zivin, J. A., G. W. Albers, N. Bornstein, T. Chippendale, B. Dahlof, T. Devlin, M. Fisher, W. Hacke, W. Holt, S. Ilic, S. Kasner, R. Lew, M. Nash, J. Perez, M. Rymer, P. Schellinger, D. Schneider, S. Schwab, R. Veltkamp, M. Walker and J. Streeter (2009) NeuroThera Effectiveness and Safety Trial-2 Investigators. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke 40, 13591364.
  • 40
    Tafur, J. and P. J. Mills (2008) Low-intensity light therapy: Exploring the role of redox mechanisms. Photomed. Laser Surg. 26, 323328.
  • 41
    Aimbire, F., R. Albertine, R. G. de Magalhães, R. A. Lopes-Martins, H. C. Castro-Faria-Neto, R. A. Zângaro, M. C. and M. T. Pacheco (2005) Effect of LLLT Ga-Al-As (685 nm) on LPS-induced inflammation of the airway and lung in the rat. Lasers Med. Sci. 20, 1120.
  • 42
    de Lima, F. M., J. M. , R. Albertini, F. V. Santos and F. Aimbire (2010) Low-level laser therapy (LLLT) attenuates RhoA mRNA expression in the rat bronchi smooth muscle exposed to tumor necrosis factor-alpha. Lasers Med. Sci. 25, 661668.
  • 43
    Aimbire, F., R. A Lopes-Martins, R. Albertini, M. T. Pacheco, H. C. Castro-Faria-Neto, P. S Martins and J. M. Bjordal (2007) Effect of low-level laser therapy on hemorrhagic lesions induced by immune complex in rat lungs. Photomed. Laser Surg. 25, 112117.
  • 44
    Cavriani, G., H. V. Domingos, A. L. Soares, A. G. Trezena, A. P. Ligeiro-Oliveira, R. M. Oliveira-Filho, L. S. Sudo-Hayashi and W. Tavares de Lima (2005) Lymphatic system as a path underlying the spread of lung and gut injury after intestinal ischemia/reperfusion in rats. Shock 23, 330336.
  • 45
    Mafra de Lima, F., K. T. Naves, A. H. Machado, R. Albertini, A. B. Villaverde and F. Aimbire (2009) Lung inflammation and endothelial cell damage are decreased after treatment with phototherapy (PhT) in a model of acute lung injury induced by Escherichia coli lipopolysaccharide in the rat. Cell Biol. Int. 33, 12121221.
  • 46
    Cavriani, G., R. M. Oliveira-Filho, A. G. Trezena, Z. L. da Silva, H. V. Domingos, M. J. de Arruda, S. Jancar and W. Tavares de Lima (2004) Lung microvascular permeability and neutrophil recruitment are differently regulated by nitric oxide in a rat model of intestinal ischemia-reperfusion. Eur. J. Pharmacol. 494, 241249.
  • 47
    Park, H. S., S. R. Kim and Y. C. Lee (2009) Impact of oxidative stress on lung diseases. Respirology 14, 2738.
  • 48
    Li, C. and R. M. Jackson (2002) Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am. J. Physiol. Cell Physiol. 282, 227241.
  • 49
    Impellizzeri, D., E. Esposito, E. Mazzon, I. Paterniti, R. Di Paola, P. Bramanti and S. Cuzzocrea (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem. Pharmacol. 81, 636648.
  • 50
    Zingarelli, B., M. Sheehan and P. W. Hake (2003) Peroxisome proliferator activator receptor-γ agonists, 15-deoxy-Δ12,14-PGJ2 and ciglitazone, reduces systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. J. Immunol. 171, 68276837.
  • 51
    Kaplan, J. M., J. A. Cook and P. W. Hake (2005) 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a peroxisome proliferator activated receptor γ ligand, reduces tissue leukosequestration and mortality in endotoxic shock. Shock 24, 5965.
  • 52
    Liu, D., B. X. Zeng and S. H. Zhang (2005) Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, reduces acute lung injury in endotoxemic rats. Crit. Care Med. 33, 23092316.
  • 53
    Mafra de Lima, F., M. S. Costa, R. Albertini and J. A. Silva (2009) Low level laser therapy (LLLT): Attenuation of cholinergic hyperreactivity, beta(2)-adrenergic hyporresponsiveness and TNF-alpha mRNA expression in rat bronchi segments in E. coli lipopolysaccharide-induced airway inflammation by a NF-kappaB dependent mechanism. Lasers Surg. Med. 41, 6874.
  • 54
    Aimbire, F., F. V. Santos, R. Albertini, H. C. Castro-Faria-Neto, J. Mittmann and C. Pacheco-Soares (2008) Low-level laser therapy decreases levels of lung neutrophils anti-apoptotic factors by a NF-kappaB dependent mechanism. Int. Immunopharmacol. 8, 603605.