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Killing Bacterial Spores with Blue Light: When Innate Resistance Meets the Power of Light

Authors

  • Tyler G. St. Denis,

    1. Department of Chemistry, Columbia University, New York, NY
    2. The Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
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  • Tianhong Dai,

    1. The Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
    2. Department of Dermatology, Harvard Medical School, Boston, MA
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  • Michael R. Hamblin

    Corresponding author
    1. The Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
    2. Department of Dermatology, Harvard Medical School, Boston, MA
    3. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA
    • Department of Chemistry, Columbia University, New York, NY
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Corresponding author email: hamblin@helix.mgh.harvard.edu (Michael R. Hamblin)

Abstract

This article is a highlight of the study by Maclean et al. in this issue of Photochemistry and Photobiology describing the sporicidal effects 405 nm visible light alone on endospores of the Clostridium and Bacillus genera. 1.73 kJ cm−2 was capable of reducing endospore colony-forming units by up to 4-log10. These findings have never been previously demonstrated and may be incorporated into decontamination methods that span medical, military and food preparatory applications.

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