Difficulties in communication within Mind, Brain, and Education (MBE) can arise from several sources. One source is differences in orientation among the areas of research, policy, and practice. Another source is lack of understanding of the entrenched and unspoken differences across research disciplines in MBE—that is, recognition that research in MBE comes from many diverse disciplines, rather than some monolithic entity. A third challenge to communication in MBE arises from the nature of studying the mind and brain; we address the different levels of analysis in mind–brain research. Throughout our article, we emphasize that recognizing these differences—across areas (research, practice, and policy), disciplines, and levels of analysis—and making them explicit can facilitate effective communication in MBE. We illustrate these concepts with examples from the study of reading disorders across several disciplines.