- Top of page
- EPIDEMIOLOGICAL EVIDENCE
- HOST GENETIC FACTORS AND GENETIC SUSCEPTIBILITY TO GC
- EXPERIMENTAL EVIDENCE
- POPULATION-BASED SCREENING
- CURRENT RECOMMENDATIONS AND OUTLOOK
Gastric cancer in the absence of strategies implemented for early detection continues to have a dismal prognosis. There are limited options for a curative therapy once patients present with clinical manifestations of this malignant disease. Helicobacter pylori (H. pylori) infection plays a key role in gastric carcinogenesis, supported by epidemiological, preclinical and clinical studies. The recognition of H. pylori infection as a critical risk factor in the development of gastric cancer opens the chance for new venues in prevention strategies.