Vitamin D receptor gene polymorphism and ulcerative colitis susceptibility in Han Chinese
Article first published online: 14 MAR 2011
© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Journal of Digestive Diseases
Volume 12, Issue 2, pages 90–98, April 2011
How to Cite
PEI, F. H., WANG, Y. J., GAO, S. L., LIU, B. R., DU, Y. J., LIU, W., YU, H. Y., ZHAO, L. X. and CHI, B. R. (2011), Vitamin D receptor gene polymorphism and ulcerative colitis susceptibility in Han Chinese. Journal of Digestive Diseases, 12: 90–98. doi: 10.1111/j.1751-2980.2011.00483.x
- Issue published online: 14 MAR 2011
- Article first published online: 14 MAR 2011
- Accepted manuscript online: 28 JAN 2011 08:47PM EST
- Han Chinese;
- ulcerative colitis;
- vitamin D receptor gene
OBJECTIVE: Specific polymorphisms in the vitamin D receptor (VDR) gene have been associated with genetic susceptibility to inflammatory bowel disease (IBD) in different ethnic populations.
METHODS: A total of 218 ulcerative colitis (UC) patients and 251 healthy controls were genotyped for VDR gene polymorphisms using PCR-restriction fragment length polymorphism (PCR-RFLP) assay. VDR gene polymorphisms (Apa I, Taq I, Bsm I and Fok I) were analyzed for both genotypic and phenotypic susceptibilities.
RESULTS: Among the four examined VDR gene polymorphisms, the Bsm I polymorphism showed a slightly higher distribution in our study population than that in the previous studies. We also found that the increased frequency of the Bb genotype of the Bsm I VDR gene polymorphism was associated with UC in Han Chinese, as compared with healthy controls (28.4% vs. 18.7%, χ2 = 6.044, P = 0.014, OR = 1.739, 95% CI = 1.122–2.697). Moreover, Bsm I polymorphic allele (B) frequency was significantly increased in the UC cases, as compared to the healthy controls (14.7% vs. 7.8% χ2 = 6.222, P = 0.013; OR = 1.670, 95% CI = 1.113–2.506). In contrast, the other three VDR gene polymorphisms (Apa I, Taq I and Fok I) were not associated with UC susceptibility in the Han Chinese cohort. In addition, none of these four VDR polymorphisms had statistical association with clinicopathological parameters of these UC patients.
CONCLUSION: This study demonstrated a probable association of the Bsm I polymorphism of the VDR gene with ulcerative colitis susceptibility in Han Chinese.