These two authors contributed equally to this work.
Epidemiological study of colorectal adenoma and cancer in symptomatic patients in China between 1990 and 2009
Article first published online: 29 SEP 2011
© 2011 The Authors. Journal of Digestive Diseases © 2011 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Journal of Digestive Diseases
Volume 12, Issue 5, pages 371–378, October 2011
How to Cite
CHEN, H. M., WENG, Y. R., JIANG, B., SHENG, J. Q., ZHENG, P., YU, C. G. and FANG, J. Y. (2011), Epidemiological study of colorectal adenoma and cancer in symptomatic patients in China between 1990 and 2009. Journal of Digestive Diseases, 12: 371–378. doi: 10.1111/j.1751-2980.2011.00531.x
Conflicts of interest: The authors declare that there is no conflict of interest.
- Issue published online: 29 SEP 2011
- Article first published online: 29 SEP 2011
- Accepted manuscript online: 21 JUL 2011 07:23AM EST
- advanced colorectal adenoma;
- clinicopathological characteristic;
- colorectal cancer;
- detection rate
OBJECTIVE: The best cure for colorectal cancer (CRC) lies on its early diagnosis and treatment. We aimed to provide the epidemiological features of advanced colorectal adenoma (A-CRA) and CRC in symptomatic patients and to determine whether the incidences of A-CRA and CRC increased simultaneously in China between 1990 and 2009.
METHODS: A total of 157 943 patients who had undergone a colonoscopy from 1990 to 2009 were enrolled, of which 6 777 patients had A-CRA and 3 503 had CRC. They were compared with controls in a stratified analysis. The detection rates of A-CRA and CRC in the 1990s and 2000s were also compared.
RESULTS: The detection rate of A-CRA increased 1.88-fold over the two decades, while that of CRC increased 0.66-fold. The percentages of patients with A-CRA and CRC who were elder than 50 years were significantly higher in the 2000s than those in the 1990s (P = 0.000). The changes of location of A-CRA and CRC during the two decades indicated a shift of lesions from the distal colon to proximal colon.
CONCLUSION: There was a significant increase in detection rate of A-CRA in the 2000s, but CRC did not increase at a similar speed. Our results indicated that the early detection and removal of colorectal adenoma in symptomatic patients might decrease the incidence of CRC.