The authors report no conflicts of interest or relevant financial relationships.
A Second Look
Vaginal Progesterone to Prevent Preterm Birth in High-Risk Women
Article first published online: 14 JUN 2012
© 2012 AWHONN
Nursing for Women's Health
Volume 16, Issue 3, pages 237–241, June / July 2012
How to Cite
FONTENOT, H. B. and FANTASIA, H. C. (2012), Vaginal Progesterone to Prevent Preterm Birth in High-Risk Women. Nursing for Women's Health, 16: 237–241. doi: 10.1111/j.1751-486X.2012.01735.x
- Issue published online: 14 JUN 2012
- Article first published online: 14 JUN 2012
- preterm birth;
- preterm delivery;
- preterm labor;
- high-risk pregnancy
Preterm birth is a significant problem in the United States, contributing to neonatal morbidity and mortality. Progesterone is a hormone naturally produced by the corpus luteum and the placenta in early pregnancy and is essential for maintaining pregnancy. Clinicians and researchers have used this hormone in later gestation to try to prevent preterm birth. However, mechanisms of action, indications for use, dosing and administration have varied and are not fully understood. This article revisits two recent randomized controlled trials in which researchers investigated the effectiveness of vaginal progesterone suppositories and gel in the prevention of preterm birth among women who were at high risk for delivering prematurely.