Cryoglobulin detection from blood and peritoneal fluid smears


Dr Jean-François Lesesve, Service d’Hématologie, CHU Nancy, France. Tel.: (33) 03 83 15 37 66; Fax: (33) 03 83 15 37 89; E-mail:


Laboratory identification of cytoplasmic inclusions in leucocytes as unusual manifestation of cryoglobulinemia has been previously reported (Maitra et al., 2000 American Journal of Clinical Pathology, 113, 107–112; Fohlen-Walter et al., 2002American Journal of Clinical Pathology, 117, 606–614.). We would like to add two observations highlighting the following: (i) the peculiar picture of cryoglobulins in neutrophils and monocytes but sparing other white blood cell (WBC) and (ii) possibility of deposit occurrence with morphological identification in body fluids.