The authors used the meta-analytic approach to examine the effects of aerobic exercise on non–high-density lipoprotein cholesterol (non–HDL-C) in children and adolescents. Thirteen non–HDL-C outcomes in 404 males and females (221 exercise, 183 control) were available for pooling. Random-effects modeling yielded a nonstatistically significant exercise minus control group reduction of 0.61% in non–HDL-C (inline image±SEM, −0.7±2.4 mg/dL, 95% confidence interval [CI], −5.4 to 5.0 mg/dL). A statistically significant decrease of 7% was found for percent body fat (inline image±SEM, −2.1±0.5%, 95% CI, −3.0 to −1.2%) as well as an 8% increase in aerobic capacity (inline image±SEM, 3.4±1.0 mL/kg/min, 95% CI, 1.4–5.3 mL/kg/min), both secondary outcomes of the study. It was concluded that aerobic exercise does not reduce non–HDL-C but does improve percent body fat and aerobic capacity in children and adolescents. However, a need exists for additional studies on this topic.