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Expression of Vinculin in Autoimmune Cutaneous Diseases

Authors

  • Yonit Wohl MD,

    1. From the Departments of Dermatology1 and Pathology,2Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine,3Tel Aviv University, Tel Aviv, Israel; and Clinical Laboratory Unit, Health Science Faculty, Ben-Gurion University of the Negev, Beer Sheva, Israel4
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  • 1,3 Ilan Goldberg MD,

    1. From the Departments of Dermatology1 and Pathology,2Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine,3Tel Aviv University, Tel Aviv, Israel; and Clinical Laboratory Unit, Health Science Faculty, Ben-Gurion University of the Negev, Beer Sheva, Israel4
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  • 1 Andrea Gat MD,

    1. From the Departments of Dermatology1 and Pathology,2Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine,3Tel Aviv University, Tel Aviv, Israel; and Clinical Laboratory Unit, Health Science Faculty, Ben-Gurion University of the Negev, Beer Sheva, Israel4
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  • 2 Osnat Ron-Tal BMedLSc,

    1. From the Departments of Dermatology1 and Pathology,2Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine,3Tel Aviv University, Tel Aviv, Israel; and Clinical Laboratory Unit, Health Science Faculty, Ben-Gurion University of the Negev, Beer Sheva, Israel4
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  • and 4 Sarah Brenner MD 1,3

    1. From the Departments of Dermatology1 and Pathology,2Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine,3Tel Aviv University, Tel Aviv, Israel; and Clinical Laboratory Unit, Health Science Faculty, Ben-Gurion University of the Negev, Beer Sheva, Israel4
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Sarah Brenner, MD, Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
E-mail: derma@tasmc.health.gov.il

Abstract

Background. Reports have appeared that sera of patients with systemic autoimmune disorders have demonstrated autoantibodies to vinculin.

Objective. To determine the presence and distribution of vinculin in the skin of patients with cutaneous autoimmune disorders.

Methods. Semiquantitative immunohistochemistry investigations for presence of vinculin were conducted on skin biopsy specimens from patients with pemphigus vulgaris (PV), bullous pemphigoid (BP), and various collagen vascular diseases, and from healthy controls.

Results. Results of staining for vinculin were positive in 2 of 7 PV patients, 6 of 9 BP patients, and all 6 cutaneous autoimmune patients. Staining results were negative in all controls. Strong immunostaining to vinculin was found in 3 of 6 vinculin-positive BP patients and 5 of 6 vinculin-positive cutaneous autoimmune patients.

Conclusions. The expression and distribution of vinculin are accentuated in patients with various skin autoimmune diseases and appear to be stronger in diseases involving the basement membrane, where it is thought to be relatively more important than in other skin disorders.

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