Hydrogels as a Platform for Stem Cell Delivery to the Heart
Article first published online: 9 MAR 2010
© 2010 Wiley Periodicals, Inc.
Congestive Heart Failure
Volume 16, Issue 3, pages 132–135, May/June 2010
How to Cite
Kurdi, M., Chidiac, R., Hoemann, C., Zouein, F., Zgheib, C. and Booz, . G. W. . (2010), Hydrogels as a Platform for Stem Cell Delivery to the Heart. Congestive Heart Failure, 16: 132–135. doi: 10.1111/j.1751-7133.2010.00145.x
- Issue published online: 11 MAY 2010
- Article first published online: 9 MAR 2010
Stem cell therapy offers great promise to repair the injured or failing heart. The outcomes of clinical trials to date, however, have shown that the actual benefit realized falls far short of the promise. A number of factors may explain why that is the case, but poor stem cell retention and engraftment in the hostile environment of the injured heart would seem to be a major factor. Improving stem cell retention and longevity once delivered would seem a logical means to enhance their reparative function. One way to accomplish this goal may be injectable hydrogels, which would serve to fix stem cells in place while providing a sheltering environment. Hydrogels also provide a means to allow for the paracrine factors produced by encapsulated stem cells to diffuse into the injured myocardium. Alternatively, hydrogels themselves can be used for the sustained delivery of reparative factors. Here the authors discuss chitosan-based hydrogels. Congest Heart Fail. 2010;16:132–135. © 2010 Wiley Periodicals, Inc.