Hydrogels as a Platform for Stem Cell Delivery to the Heart

Authors

  • Mazen Kurdi PhD ,

    1. From the Department of Chemistry and Biochemistry, Faculty of Sciences, The Lebanese University, Rafic Hariri Educational Campus, Hadath, Lebanon;
    2. Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS;
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  • Rony Chidiac BS ,

    1. Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS;
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  • Caroline Hoemann PhD ,

    1. the Department of Chemical Engineering and Institute for Biomedical Engineering, École Polytechnique Montréal, Montreal, QC, Canada
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  • Fouad Zouein BS ,

    1. Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS;
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  • Carlos Zgheib MS ,

    1. Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS;
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  • George W. Booz PhD

    1. Department of Pharmacology and Toxicology, School of Medicine, and the Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS;
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George W. Booz, PhD, University of Mississippi Medical Center, Department of Pharmacology and Toxicology, 2500 North State Street, Jackson, MS 39216-4505
E-mail: gbooz@pharmacology.umsmed.edu

Abstract

Stem cell therapy offers great promise to repair the injured or failing heart. The outcomes of clinical trials to date, however, have shown that the actual benefit realized falls far short of the promise. A number of factors may explain why that is the case, but poor stem cell retention and engraftment in the hostile environment of the injured heart would seem to be a major factor. Improving stem cell retention and longevity once delivered would seem a logical means to enhance their reparative function. One way to accomplish this goal may be injectable hydrogels, which would serve to fix stem cells in place while providing a sheltering environment. Hydrogels also provide a means to allow for the paracrine factors produced by encapsulated stem cells to diffuse into the injured myocardium. Alternatively, hydrogels themselves can be used for the sustained delivery of reparative factors. Here the authors discuss chitosan-based hydrogels. Congest Heart Fail. 2010;16:132–135. © 2010 Wiley Periodicals, Inc.

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