The authors examined the effects of aerobic exercise on selected coronary heart disease (CHD) risk factors using data from previously published meta-analyses. Using a random effects model, the effects of aerobic exercise on glycosylated hemoglobin (HbA1c) (mean, 95% confidence interval, −0.9%, −1.9% to 0.03%), resting systolic blood pressure (−6.9 mm Hg, −9.1 to −4.6 mm Hg), low-density lipoprotein cholesterol (−3.1 mg/dL, −6.1 to 0 mg/dL), and body mass index (−1.3 kg/m2, −2.5 to −0.1 kg/m2) were either statistically significant or demonstrated a trend for statistical significance. Changes were equivalent to relative reductions of −8.5%, −4.7%, −2.0%, and −4.5%, respectively. Changes corresponded to estimated 5-year reductions in CHD mortality of 14%, 17%, 1.5%, and 5%, respectively. The results of this review reinforce the idea that aerobic exercise is an important nonpharmacologic intervention for improving selected CHD risk factors.