Risk Factors for Subclinical Carotid Atherosclerosis Among Current Smokers
Article first published online: 12 MAR 2010
© 2010 Wiley Periodicals, Inc.
Volume 13, Issue 4, pages 166–171, Fall 2010
How to Cite
Johnson, H. M., Piper, M. E., Jorenby, D. E., Fiore, M. C., Baker, T. B. and Stein, J. H. (2010), Risk Factors for Subclinical Carotid Atherosclerosis Among Current Smokers. Preventive Cardiology, 13: 166–171. doi: 10.1111/j.1751-7141.2010.00068.x
- Issue published online: 12 MAR 2010
- Article first published online: 12 MAR 2010
- Manuscript received October 14, 2009; revised December 28, 2009; accepted January 20, 2010
This study characterized the determinants of carotid atherosclerosis in a large contemporary sample of current smokers. Associations between risk factors, carotid intima-media thickness (CIMT), and carotid plaque presence were determined by multivariable regression. Participants included 1504 current smokers (58% female) who were a median (interquartile range) of 44.7 (38–53) years old and smoked 25 (15–40) pack-years; 55% had plaque. Pack-years, age, male sex, nonwhite race, body mass index, systolic blood pressure, small low-density lipoproteins (LDLs), and total high-density lipoproteins were independently associated with CIMT (model R2=0.434, P<.001). Pack-years (odds ratio [OR], 1.14 per 10 pack-years; P=.001), age (OR, 1.75 per 10 years; P<.001), body mass index (OR, 0.91 per 5 kg/m2; P=.035), and small LDLs (OR, 1.11 per 100 nmol/L; P<.001) were independently associated with carotid plaque presence (model χ2=210.7, P<.001). The association between pack-years and carotid plaque was stronger in women (OR, 1.09 per 10 pack-years, Pinteraction=.018).
Prev Cardiol. 2010;13:166–171.©2010 Wiley Periodicals, Inc.