Is Acute High-Dose Secondhand Smoke Exposure Always Harmful to Microvascular Function in Healthy Adults?
Article first published online: 20 MAY 2010
© 2010 Wiley Periodicals, Inc.
Volume 13, Issue 4, pages 175–179, Fall 2010
How to Cite
Bard, R. L., Dvonch, J. T., Kaciroti, N., Lustig, S. A. and Brook, R. D. (2010), Is Acute High-Dose Secondhand Smoke Exposure Always Harmful to Microvascular Function in Healthy Adults?. Preventive Cardiology, 13: 175–179. doi: 10.1111/j.1751-7141.2010.00074.x
- Issue published online: 20 MAY 2010
- Article first published online: 20 MAY 2010
- Manuscript received November 12, 2009; revised January 28, 2010; accepted March 8, 2010
Long-term exposure to secondhand smoke (SHS) is associated with impaired vascular function. The authors investigated the vascular and blood pressure (BP) reactions to acute SHS exposure. Twenty-five healthy nonsmoking adults underwent a 1-hour exposure to SHS (mean fine particulate matter <2.5 μm level=315±116 μg/m3). Microvascular endothelial-dependent vasodilatation (EDV) (EndoPAT, Itamar Medical, Caesarea, Israel) and aortic hemodynamics/compliance (SphygmoCor, AtCor Medical, West Ryde, Australia) were measured before and after the SHS exposure with BP measured every 15 minutes during and for a 24-hour period before and after the exposure. SHS exposure did not change EDV, aortic hemodynamics, arterial compliance, or 24-hour BP. However, diastolic BP significantly increased during the SHS exposure period by 3.4±5.6 mm Hg. Our brief SHS exposure did not impair microvascular endothelial function or arterial compliance in healthy nonsmoking adults, but brachial diastolic BP increased.
Prev Cardiol. 2010;13:175–179.©2010 Wiley Periodicals, Inc.