Masked Hypertension Defined by Ambulatory Blood Pressure Monitoring Is Associated With an Increased Serum Glucose Level and Urinary Albumin-Creatinine Ratio

Authors

  • Joji Ishikawa MD, PhD,

    1. From the Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, Tochigi, Japan;
    2. the Center for Behavioral Cardiovascular Health, Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY
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  • Satoshi Hoshide MD,

    1. From the Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, Tochigi, Japan;
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  • Kazuo Eguchi MD, PhD,

    1. From the Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, Tochigi, Japan;
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  • Joseph E. Schwartz PhD,

    1. the Center for Behavioral Cardiovascular Health, Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY
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  • Thomas G. Pickering MD, DPhil,

    1. the Center for Behavioral Cardiovascular Health, Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY
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  • Kazuyuki Shimada MD, PhD,

    1. From the Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, Tochigi, Japan;
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  • Kazuomi Kario MD, PhD

    1. From the Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, Tochigi, Japan;
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Joji Ishikawa, MD, PhD, Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
E-mail: george@jichi.ac.jp

Abstract

J Clin Hypertens(Greenwich). 2010;12:578–587. © 2010 Wiley Periodicals, Inc.

The authors evaluated the relationship of hypertensive target organ damage to masked hypertension assessed by ambulatory blood pressure (BP) and home blood pressure (HBP) monitoring in 129 participants without taking antihypertensive medication. Masked hypertension was defined as office BP ≤140/90 mm Hg and 24-hour ambulatory BP ≥130/80 mm Hg. The masked hypertensive participants defined by 24-hour ambulatory BP (n=13) had a higher serum glucose level (126 vs 96 mg/dL, P=.001) and urinary albumin-creatinine ratio (38.0 vs 7.5 mg/gCr, P<.001) than the normotensive participants (n=74); however, these relationships were not observed when the authors defined groups using HBP (≥135/85 mm Hg). Masked hypertension by both 24-hour ambulatory BP and HBP had a higher urinary albumin-creatinine ratio than normotension by both 24-hour ambulatory BP and HBP (62.1 vs 7.4 mg/gCr, P=.001), and than masked hypertension by HBP alone (9.3 mg/gCr, P=.009). Masked hypertension defined by 24-hour ambulatory BP is associated with an increased serum glucose level and urinary albumin-creatinine ratio, but these relationships are not observed in masked hypertension defined by HBP.

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