Masked Hypertension Defined by Ambulatory Blood Pressure Monitoring Is Associated With an Increased Serum Glucose Level and Urinary Albumin-Creatinine Ratio
Article first published online: 6 APR 2010
© 2010 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 12, Issue 8, pages 578–587, August 2010
How to Cite
Ishikawa, J., Hoshide, S., Eguchi, K., Schwartz, J. E., Pickering, T. G., Shimada, K. and Kario, K. (2010), Masked Hypertension Defined by Ambulatory Blood Pressure Monitoring Is Associated With an Increased Serum Glucose Level and Urinary Albumin-Creatinine Ratio. The Journal of Clinical Hypertension, 12: 578–587. doi: 10.1111/j.1751-7176.2010.00286.x
- Issue published online: 2 AUG 2010
- Article first published online: 6 APR 2010
- Manuscript received August 24, 2009; revised January 7, 2010; accepted January 10, 2010
J Clin Hypertens(Greenwich). 2010;12:578–587. © 2010 Wiley Periodicals, Inc.
The authors evaluated the relationship of hypertensive target organ damage to masked hypertension assessed by ambulatory blood pressure (BP) and home blood pressure (HBP) monitoring in 129 participants without taking antihypertensive medication. Masked hypertension was defined as office BP ≤140/90 mm Hg and 24-hour ambulatory BP ≥130/80 mm Hg. The masked hypertensive participants defined by 24-hour ambulatory BP (n=13) had a higher serum glucose level (126 vs 96 mg/dL, P=.001) and urinary albumin-creatinine ratio (38.0 vs 7.5 mg/gCr, P<.001) than the normotensive participants (n=74); however, these relationships were not observed when the authors defined groups using HBP (≥135/85 mm Hg). Masked hypertension by both 24-hour ambulatory BP and HBP had a higher urinary albumin-creatinine ratio than normotension by both 24-hour ambulatory BP and HBP (62.1 vs 7.4 mg/gCr, P=.001), and than masked hypertension by HBP alone (9.3 mg/gCr, P=.009). Masked hypertension defined by 24-hour ambulatory BP is associated with an increased serum glucose level and urinary albumin-creatinine ratio, but these relationships are not observed in masked hypertension defined by HBP.