Evaluation of N-Terminal Prohormone B-Type Natriuretic Peptide in Patients With Acute Coronary Syndromes and Percutaneous Coronary Intervention
Version of Record online: 5 NOV 2010
© 2010 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 12, Issue 11, pages 861–868, November 2010
How to Cite
Lampropoulos, K. M., Marinakis, A., Sokolis, D. P. and Iliopoulos, T. A. (2010), Evaluation of N-Terminal Prohormone B-Type Natriuretic Peptide in Patients With Acute Coronary Syndromes and Percutaneous Coronary Intervention. The Journal of Clinical Hypertension, 12: 861–868. doi: 10.1111/j.1751-7176.2010.00354.x
- Issue online: 5 NOV 2010
- Version of Record online: 5 NOV 2010
- Manuscript received January 19, 2010; revised May 2, 2010; accepted May 13, 2010
J Clin Hypertens (Greenwich). ©2010 Wiley Periodicals, Inc.
The aim of this research was to describe N-terminal part of the prohormone B-type natriuretic peptide (NT-proBNP) levels over time in patients with acute coronary syndrome (ACS) before and after percutaneous coronary intervention (PCI). NT-proBNP, troponin I (Tn-I), creatine kinase (CK), CK MB isoenzyme (CKMB), fibrinogen, D-dimers, and C-reactive protein (CRP) were measured in 300 consecutive patients with ACS before undergoing successful reperfusion with PCI in the first 48 hours, 2 days after, and at the end of the 1st, 3rd, 6th, 12th, 18th, and 24th month. The concentration of NT-proBNP was cross-correlated with the levels of NT-proBNP in 300 patients without ACS and was significantly increased before and after PCI and at the end of the 3rd month, contrasting with the fast conversion to normal levels of Tn-I, CK, CKMB, fibrinogen, D-dimers, and CRP. In patients with ACS undergoing successful PCI, NT-proBNP shows slow kinetics, especially in patients with an increased thrombolysis in myocardial infarction risk score, hypertension, and diabetes. Nevertheless, cardiac neurohormonal activation may be a unifying feature among patients at high risk for cardiovascular events after ACS and PCI. J Clin Hypertens (Greenwich). 2010;12:861–868.