High Prevalence of Liddle Syndrome Phenotype Among Hypertensive US Veterans in Northwest Louisiana
Article first published online: 20 AUG 2010
© 2010 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 12, Issue 11, pages 856–860, November 2010
How to Cite
Tapolyai, M., Uysal, A., Dossabhoy, N. R., Zsom, L., Szarvas, T., Lengvárszky, Z. and Fülöp, T. (2010), High Prevalence of Liddle Syndrome Phenotype Among Hypertensive US Veterans in Northwest Louisiana. The Journal of Clinical Hypertension, 12: 856–860. doi: 10.1111/j.1751-7176.2010.00359.x
- Issue published online: 5 NOV 2010
- Article first published online: 20 AUG 2010
- Manuscript received March 19, 2010; revised June 11, 2010; accepted June 22, 2010
J Clin Hypertens (Greenwich).
Liddle syndrome (LS) is an autosomal dominant disorder due to a gain-of-function mutation in the epithelial Na+ channel and is perceived to be a rare condition. A cross-sectional study of 149 hypertensive patients with hypokalemia (<4 mmol/dL) or elevated serum bicarbonate (>25 mmol/dL) was conducted at a Veterans’ Administration Medical Center Hypertension Clinic in Shreveport, LA. Data on demographics, blood pressure, and select blood tests were collected and expressed as percentages for categoric variables and as mean ± standard deviation (SD) for continuous variables. Patients were diagnosed with likely LS when the plasma renin activity (PRA) was <0.35 μU/mL/h and the aldosterone was <15 ng/dL and likely primary hyperaldosteronism (PHA) with PRA <0.35 μU/mL/h and aldosterone level >15 ng/dL. The cohort included predominantly elderly (67.1±13.4 years), male (96%), and Caucasian (57%) patients. The average blood pressure was 143.8/79.8 mm Hg±27.11/15.20 with 3.03±1.63 antihypertensive drugs. Based on the above criteria, 9 patients (6%) satisfied the criteria for likely LS and 10 patients (6.7%) were diagnosed with likely PHA. In this hypothesis-generating study, the authors detected an unusually high prevalence of biochemical abnormalities compatible with likely LS syndrome from Northwestern Louisiana, approaching that of likely PHA. J Clin Hypertens (Greenwich). 2010;12:856–860.