Research Vascular Laboratory, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI
Determinants of Vascular Function in Patients With Chronic Gout
Article first published online: 22 DEC 2010
© 2010 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 13, Issue 3, pages 178–188, March 2011
How to Cite
Brook, R. D., Yalavarthi, S., Myles, J. D., Khalatbari, S., Hench, R., Lustig, S., Marder, W., Neidert, A. and Kaplan, M. J. (2011), Determinants of Vascular Function in Patients With Chronic Gout. The Journal of Clinical Hypertension, 13: 178–188. doi: 10.1111/j.1751-7176.2010.00406.x
- Issue published online: 2 MAR 2011
- Article first published online: 22 DEC 2010
- Manuscript received August 23, 2010; revised October 26, 2010; accepted October 28, 2010
Epidemiologic studies have proposed a relationship between hyperuricemia and cardiovascular (CV) risk. However, it is unclear whether uric acid (UA) is an independent risk factor for CV disease (CVD) after controlling for other predisposing conditions. Gout patients might have persistent systemic inflammation, which, in addition to hyperuricemia, may potentiate CVD. This study examined vascular function and markers of CV damage in gout patients when compared with healthy controls. Brachial artery flow-mediated dilatation, arterial compliance, and microvascular function were measured. Circulating apoptotic endothelial cells and endothelial progenitor cells were quantified by FACS and circulating biomarkers of CVD by enzyme-linked immunosorbent assay. Gout patients displayed significant increases in body mass index, C-reactive protein, UA, and triglycerides and decreases in high-density lipoprotein. There were no significant differences in other CV traditional risk factors, adhesion molecules, or chemokines. Gout patients did not differ from controls in vascular function. In univariate and multivariate analysis, UA was not associated with the quantified CV risk parameters. Despite an increase in several CV risk factors, inflammation, and UA, gout patients display normal endothelial function and no increases in biomarkers of CVD. These results do not support the notion that gout is an independent risk factor for premature CVD. J Clin Hypertens (Greenwich). 2011;13:178–188. © 2010 Wiley Periodicals, Inc.