- Top of page
- Randomized Trials Before PROGRESS
- Main Results of PROGRESS
- Effects of BP Lowering on Stroke Subtypes
- Effects of BP Lowering on Cognitive Function
- Effects of BP Lowering in Clinically Important Subgroups
- Threshold for BP Lowering and Optimal Target BP in Secondary Prevention of Stroke
- Patients With Large Artery Stenosis
- Randomized Trials After PROGRESS
- Different Classes of BP-Lowering Drugs in Prevention of Stroke
- Source of Funding
J Clin Hypertens (Greenwich). 2011;13;693–702. ©2011 Wiley Periodicals, Inc.
The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized placebo-controlled trial which clearly demonstrated that perindopril-based blood pressure (BP)–lowering treatment is one of the most effective and generalizable strategies for secondary prevention of stroke. Beneficial effects of BP lowering were observed on recurrent stroke, other cardiovascular events, disability, dependency, and cognitive function across a variety of subgroups defined by age, sex, geographical region, body mass index, diabetes, atrial fibrillation, chronic kidney disease, and baseline BP levels. Once patients with stroke have stabilized, all patients should receive BP-lowering therapy irrespective of their BP levels. On the basis of recommendations from current international guidelines, BP should be lowered to <140/90 mm Hg in all patients with cerebrovascular disease and to <130/80 mm Hg if therapy is well tolerated.