Uric Acid, Hypertension, and Chronic Kidney Disease Among Alaska Eskimos: The Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study
Version of Record online: 4 JAN 2012
© 2011 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 14, Issue 2, pages 71–77, February 2012
How to Cite
Jolly, S. E., Mete, M., Wang, H., Zhu, J., Ebbesson, S. O.E., Voruganti, V. S., Comuzzie, A. G., Howard, B. V. and Umans, J. G. (2012), Uric Acid, Hypertension, and Chronic Kidney Disease Among Alaska Eskimos: The Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. The Journal of Clinical Hypertension, 14: 71–77. doi: 10.1111/j.1751-7176.2011.00574.x
- Issue online: 25 JAN 2012
- Version of Record online: 4 JAN 2012
- Manuscript received: September 24, 2011; Revised: October 28, 2011; Accepted: November 5, 2011
J Clin Hypertens (Greenwich).****;**:**–**. ©2011 Wiley Periodicals, Inc.
It is unknown what role uric acid (UA) may play in the increasing rates of cardiovascular disease (CVD) among Alaska Eskimos. UA is associated with both hypertension (HTN) and chronic kidney disease (CKD). The authors analyzed 1078 Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) participants. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine measures using the Modification of Diet in Renal Disease equation. CKD was defined by an eGFR of <60 mL/min/1.73 m2. The authors adjusted for age, sex, education, diabetes, hypertension (or eGFR), obesity, lipids, and smoking status; 7% (n=75) had prevalent CKD. eGFR decreased with increasing tertiles of serum UA (P<.001). UA was independently associated with prevalent CKD (adjusted odds ratio [OR] and 95% confidence interval [CI] of 2.04 (1.62–2.56), respectively). Twenty-one percent (n=230) had prevalent HTN and UA was independently associated with prevalent HTN (adjusted OR, 1.2; 95% CI, 1.1–1.5). UA is independently associated with prevalent CKD and HTN in this population.