Details of the TEAMSTA Severe HTN Study Investigators (see Appendix).
Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study
Version of Record online: 23 FEB 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 14, Issue 4, pages 206–215, April 2012
How to Cite
Neutel, J. M., Mancia, G., Black, H. R., Dahlöf, B., Defeo, H., Ley, L., Vinisko, R. and on behalf of the TEAMSTA Severe HTN Study Investigators (2012), Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study. The Journal of Clinical Hypertension, 14: 206–215. doi: 10.1111/j.1751-7176.2012.00595.x
- Issue online: 28 MAR 2012
- Version of Record online: 23 FEB 2012
- Manuscript received: September 15, 2011; Revised: December 13, 2011; Accepted: January 7, 2012
Vol. 14, Issue 10, 735, Version of Record online: 10 SEP 2012
J Clin Hypertens (Greenwich). 2012;14:206–215. ©2012 Wiley Periodicals, Inc.
This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mm Hg). At 8 weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (−47.5 mm Hg/−18.7 mm Hg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6 weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.