These authors contributed equally to this work.
Improvement of Arterial Stiffness by Reducing Oxidative Stress Damage in Elderly Hypertensive Patients After 6 Months of Atorvastatin Therapy
Article first published online: 6 MAR 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 14, Issue 4, pages 245–249, April 2012
How to Cite
Wang, J., Xu, J., Zhou, C., Zhang, Y., Xu, D., Guo, Y. and Yang, Z. (2012), Improvement of Arterial Stiffness by Reducing Oxidative Stress Damage in Elderly Hypertensive Patients After 6 Months of Atorvastatin Therapy. The Journal of Clinical Hypertension, 14: 245–249. doi: 10.1111/j.1751-7176.2012.00600.x
- Issue published online: 28 MAR 2012
- Article first published online: 6 MAR 2012
- Manuscript received: November 9, 2011; Revised: December 20, 2011; Accepted: January 7, 2012
J Clin Hypertens (Greenwich). 2012;14:245–249. ©2012 Wiley Periodicals, Inc.
Atorvastatin is postulated to improve arterial stiffness in patients with diabetes mellitus or hypercholesterolemia; however, in elderly hypertensive patients, its effect on arterial stiffness and the possible mechanisms are unknown. A total of 73 elderly hypertensive patients were enrolled to receive atorvastatin for 6 months. Brachial-ankle pulse wave velocity (baPWV) and circulating biomarkers were measured before and after the intervention. After 6 months of treatment, the patients experienced a 19.66% reduction in low-density lipoprotein cholesterol (2.90±0.58 vs 2.33±0.56 mmol/L, P<.01) and a 10.63% reduction in baPWV (2100.89±513.21 vs 1877.56±432.06 cm/s, P=.01). In addition, a 21.79% reduction in circulating N-(epsilon)-carboxymethyl-lysine and a 20% reduction in Von Willebrand factor level were observed after treatment. Meanwhile, the activity of copper/zinc-containing superoxide dismutase (Cu/Zn SOD) was increased by 26.64% (5.04±1.01 vs 6.87±1.83 U/L, P<.001). Correlation analysis demonstrated that the increase of Cu/Zn SOD activity was related to the reductions of arterial stiffness (r=−0.340, P=.003). Taken together, these findings suggest that atorvastatin can improve arterial stiffness possibly by reducing oxidative stress levels in elderly hypertensive patients.