Validation of a French Version of the 8-Item Morisky Medication Adherence Scale in Hypertensive Adults

Authors

  • Virginie Korb-Savoldelli PharmD,

    1. From the Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service Pharmacie, Paris;
    2. Faculté de Pharmacie, Laboratoire de Pharmacie Clinique et Pharmacocinétique, Université Paris Descartes, Paris;
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  • Florence Gillaizeau MSc,

    1. Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d’Épidémiologie et de Recherche Clinique, Paris;
    2. INSERM, Centre D’investigation Épidémiologique, Paris;
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  • Jacques Pouchot MD, PhD,

    1. Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Médecine Interne, Paris;
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  • Emilie Lenain MSc,

    1. Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d’Épidémiologie et de Recherche Clinique, Paris;
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  • Nicolas Postel-Vinay MD, PhD,

    1. Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service d’Hypertension Artérielle, Paris;
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  • Pierre-François Plouin MD, PhD,

    1. Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service d’Hypertension Artérielle, Paris;
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  • Pierre Durieux MD, PhD,

    1. Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité d’Épidémiologie et de Recherche Clinique, Paris;
    2. INSERM, Centre D’investigation Épidémiologique, Paris;
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  • Brigitte Sabatier PharmD, PhD

    1. From the Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service Pharmacie, Paris;
    2. Université Paris Descartes, INSERM U765, Paris, France
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Virginie Korb-Savoldelli, PharmD, Hôpital Européen Georges-Pompidou, Service Pharmacie, 20 rue Leblanc, 75015 Paris, France
E-mail:virginie.savoldelli@gmail.com

Abstract

J Clin Hypertens (Greenwich). 2012; 14:429–434. © 2012 Wiley Periodicals, Inc.

The aim of this study was to validate a French translation of the structured self-report 8-item Morisky Medication Adherence Scale (MMAS-8) and determine its psychometric properties in patients taking antihypertensive medication. An observational cross-sectional study was conducted in the hypertensive unit of a French university hospital. The MMAS-8 was translated according to international guidelines. Internal consistency was assessed using Cronbach α coefficient, construct validity using principal component and confirmatory factor analyses, and the test-retest reliability at 1-month interval using the intraclass correlation coefficient (ICC). Three levels of adherence were considered (low: scores of 0 to <6; medium: 6 to <8; high: 8) and risk factors were explored in ordinal logistic regression models. A total of 199 patients were included: mean age, 55.7±14.6 years, 57.3% men (114 of 199), and 39.5% (66 of 167) had uncontrolled blood pressure. The French MMAS was moderately reliable (α=0.54), one-dimensional, and reproducible (ICC=0.68). The mean score was 6.96 (standard deviation 1.25) and 17.6% (35 of 199), 37.7% (75 of 199), and 43.7% (87 of 199) of patients had low, medium, and high adherence, respectively. The only factor significantly associated with adherence was age. The French MMAS has acceptable psychometric effects to measure medication adherence in hypertensive patients and may be useful in detecting nonadherent hypertensive patients.

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