Cerebrovascular Consequences of Pseudohyperaldosteronism
Article first published online: 3 MAY 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 14, Issue 8, pages 547–552, August 2012
How to Cite
Smith, J. H., Lindor, N. M. and Rabinstein, A. A. (2012), Cerebrovascular Consequences of Pseudohyperaldosteronism. The Journal of Clinical Hypertension, 14: 547–552. doi: 10.1111/j.1751-7176.2012.00639.x
- Issue published online: 3 AUG 2012
- Article first published online: 3 MAY 2012
- Manuscript received: January 23, 2012; Revised: February 28, 2012; Accepted: March 3, 2012
J Clin Hypertens (Greenwich). 2012;00:00–00. ©2012 Wiley Periodicals, Inc.
The study of mechanistically defined forms of hypertension may provide insight into the relationship between hypertension and stroke. The author retrospectively studied a cohort of 23 individuals with pseudohyperaldosteronism (PHA), a condition associated with pathologic activation of the distal nephron epithelial sodium channel but low renin and aldosterone levels. During a median follow-up of 11 years (range: 1–30), 4 of 23 (17.4%) patients had a cerebrovascular event recorded. Intracranial hemorrhage was not observed in any patient. Cerebrovascular events tended to occur in older patients, minorities, and patients with a later diagnosis of PHA and additional vascular risk factors. In addition to strict blood pressure control, patients with PHA should have early evaluation and treatment of other vascular risk factors to reduce the risk of stroke.