Observations on Degenerative Changes Within the Optic Nerve in Patients With Primary Open Glaucoma and Arterial Hypertension: 6-Month Follow-Up
Article first published online: 13 AUG 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 14, Issue 10, pages 701–710, October 2012
How to Cite
Krasińska, B., Banach, M., Karolczak-Kulesza, M., Krasiński, Z., Głuszek, J. and Tykarski, A. (2012), Observations on Degenerative Changes Within the Optic Nerve in Patients With Primary Open Glaucoma and Arterial Hypertension: 6-Month Follow-Up. The Journal of Clinical Hypertension, 14: 701–710. doi: 10.1111/j.1751-7176.2012.00694.x
- Issue published online: 2 OCT 2012
- Article first published online: 13 AUG 2012
- Manuscript received: April 22, 2012; revised: June 11, 2012; accepted: June 18, 2012
J Clin Hypertens (Greenwich). 2012;14:701–710. ©2012 Wiley Periodicals, Inc.
The authors aimed to determine the effect of the time of hypotensive drug administration on the progress of degenerative changes within the optic nerve in patients with hypertension and glaucoma. Two groups were included in the study: group A comprised patients-dippers taking drugs in the mornings, and group B comprised patients-nondippers taking drugs both in the mornings and in the evenings. After 6 months, group B showed significant drops in nocturnal diastolic blood pressure (BP) (month 1=73.27 mm Hg vs month 6=67.50 mm Hg), nocturnal mean BP (89.34 vs 84.65 mm Hg), and minimum diastolic BP (50.74 vs 44.03 mm Hg). Group B also showed significant reductions in nocturnal ocular perfusion pressure (43.0 vs 39.73), retinal nerve fiber layer thickness (131.31 vs 113.12 μm), and flow in the eye vessels. Taking hypotensive drugs in the evening may significantly decrease blood flow in the eye arteries, cause degenerative changes within the optic nerves, and result in greater loss in the field of vision.