Effect of Allopurinol on Blood Pressure: A Systematic Review and Meta-Analysis
Article first published online: 20 AUG 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 15, Issue 6, pages 435–442, June 2013
How to Cite
Agarwal, V., Hans, N. and Messerli, F. H. (2013), Effect of Allopurinol on Blood Pressure: A Systematic Review and Meta-Analysis. The Journal of Clinical Hypertension, 15: 435–442. doi: 10.1111/j.1751-7176.2012.00701.x
- Issue published online: 4 JUN 2013
- Article first published online: 20 AUG 2012
- Manuscript received: May 21, 2012; revised: June 20, 2012; accepted: July 4, 2012
J Clin Hypertens (Greenwich). 2013; 15:435–442 ©2012 Wiley Periodicals, Inc.
Allopurinol is a potent xanthine oxidase inhibitor that is used in hyperuricemic patients to prevent gout. It has also been shown to decrease cardiovascular complications in a myriad of cardiovascular conditions. However, studies have reported conflicting evidence on its effects on blood pressure (BP). A systematic review was conducted using Medline, PubMed, Embase, and the Cochrane Library for all the longitudinal studies that assessed the efficacy of allopurinol on systolic and diastolic BP. A total of 10 clinical studies with 738 participants were included in the analysis. Compared with the control group, systolic BP decreased by 3.3 mm Hg (95% confidence interval [CI], 1.4–5.3 mm Hg; P=.001) and diastolic BP decreased by 1.3 mm Hg (95% CI, 0.1–2.5 mm Hg; P=.03) in patients treated with allopurinol. When analysis was restricted to the higher-quality randomized controlled trials, similar changes in systolic and diastolic BPs were found: 3.3 mm Hg (95% CI, 0.8–5.8 mm Hg; P<.001) and 1.4 mm Hg (95% CI, 0.1–2.7 mm Hg; P=.04), respectively. Allopurinol is associated with a small but significant reduction in BP. This effect can be potentially exploited to aid in controlling BP in hypertensive patients with hyperuricemia.