Coronary Microvascular Function in Patients With Isolated Systolic and Combined Systolic/Diastolic Hypertension
Version of Record online: 27 AUG 2012
© 2012 Wiley Periodicals, Inc.
The Journal of Clinical Hypertension
Volume 14, Issue 12, pages 871–876, December 2012
How to Cite
Bozbas, H., Pirat, B., Yildirir, A., Eroglu, S., Simsek, V., Sade, E., Atar, I., Aydinalp, A., Ozin, B. and Muderrisoglu, H. (2012), Coronary Microvascular Function in Patients With Isolated Systolic and Combined Systolic/Diastolic Hypertension. The Journal of Clinical Hypertension, 14: 871–876. doi: 10.1111/j.1751-7176.2012.00705.x
- Issue online: 3 DEC 2012
- Version of Record online: 27 AUG 2012
- Manuscript received: April 29, 2012; revised: June 27, 2012; accepted: July 4, 2012
J Clin Hypertens (Greenwich). 2012;14:871–876. ©2012 Wiley Periodicals, Inc.
Isolated systolic hypertension (ISH) is a common condition in the elderly that is associated with endothelial dysfunction. Concerning the effect of type of hypertension on coronary microvascular function, coronary flow reserve (CFR) in patients with ISH was evaluated and the results were compared with patients with combined systolic/diastolic hypertension (SDH). Seventy-six elderly patients (older than 60 years) who were free of coronary artery disease and diabetes mellitus were enrolled in the study (38 with ISH and 38 with combined SDH). Using transthoracic Doppler echocardiography, CFR was calculated as the ratio of hyperemic to baseline diastolic peak flow velocities. A CFR value of >2 was accepted as normal. The mean age was 68.6±6.3 years and the groups had similar features with regard to demographic and clinical characteristics. Patients with ISH had significantly lower CFR values compared with those with combined SDH (2.22±0.51 vs 2.49±0.56, respectively; P=.03). On multivariate regression analysis, ISH (β=−0.40, P=.004) and dyslipidemia (β=−0.29, P=.04) were the independent predictors of CFR. These findings indicate that CFR, an indicator of coronary microvascular/endothelial function, is impaired more profoundly in patients with ISH than in patients with combined SDH.