Is there an association between neurocognitive performance and medication adherence in first episode psychosis?
Article first published online: 20 APR 2010
© 2010 Blackwell Publishing Asia Pty Ltd
Early Intervention in Psychiatry
Volume 4, Issue 2, pages 189–195, May 2010
How to Cite
Lepage, M., Bodnar, M., Joober, R. and Malla, A. (2010), Is there an association between neurocognitive performance and medication adherence in first episode psychosis?. Early Intervention in Psychiatry, 4: 189–195. doi: 10.1111/j.1751-7893.2010.00174.x
- Issue published online: 20 APR 2010
- Article first published online: 20 APR 2010
- Received 11 February 2009; accepted 19 January 2010
- medication adherence;
- medication compliance;
Aim: Medication adherence is a determining factor for symptomatic remission and relapse prevention following a first episode of psychosis (FEP). Neurocognitive abilities have received only scant attention so far as a risk factor for poor adherence but significant impairments with memory and/or planning abilities could play a role. We examined early medication adherence following admission to a specialized clinical programme for FEP.
Method: One hundred sixty FEP participants and 35 healthy controls completed an exhaustive neurocognitive assessment. FEP participants were categorized as a function of their medication adherence at 6 months into poor (n = 34), partial (n = 27) and full (n = 99) adherence, respectively. Domain-specific and global measures of cognitive ability were examined.
Results: No measure of neurocognition could significantly discriminate amongst the three medication adherence groups.
Conclusion: These results suggest no strong associations between neurocognitive abilities and medication adherence in first episode of psychosis.