Early detection and intervention evaluation for people at high-risk of psychosis-2 (EDIE-2): trial rationale, design and baseline characteristics

  1. Anthony P. Morrison1,4,*,
  2. Suzanne L.K. Stewart1,
  3. Paul French4,
  4. Richard P. Bentall5,
  5. Max Birchwood6,
  6. Rory Byrne4,
  7. Linda M. Davies2,
  8. David Fowler8,
  9. Andrew I. Gumley9,
  10. Peter B. Jones10,
  11. Shôn W. Lewis3,
  12. Graham K. Murray10,
  13. Paul Patterson7,
  14. Graham Dunn2

Article first published online: 27 JAN 2011

DOI: 10.1111/j.1751-7893.2010.00254.x

Issue

Early Intervention in Psychiatry

Early Intervention in Psychiatry

Volume 5, Issue 1, pages 24–32, February 2011

Additional Information

How to Cite

Morrison, A. P., Stewart, S. L.K., French, P., Bentall, R. P., Birchwood, M., Byrne, R., Davies, L. M., Fowler, D., Gumley, A. I., Jones, P. B., Lewis, S. W., Murray, G. K., Patterson, P. and Dunn, G. (2011), Early detection and intervention evaluation for people at high-risk of psychosis-2 (EDIE-2): trial rationale, design and baseline characteristics. Early Intervention in Psychiatry, 5: 24–32. doi: 10.1111/j.1751-7893.2010.00254.x

Author Information

  1. 1

    School of Psychological Sciences

  2. 2

    Health Sciences Research Group, School of Medicine

  3. 3

    Mental Health and Neurodegeneration Research Group, School of Medicine, University of Manchester

  4. 4

    Greater Manchester West Mental Health NHS Foundation Trust, Manchester

  5. 5

    School of Psychology, Bangor University, Bangor

  6. 6

    School of Psychology, University of Birmingham, Birmingham

  7. 7

    Early Detection and Intervention Team, Birmingham and Solihull Mental Health NHS Trust, Birmingham

  8. 8

    School of Medicine, Health Policy, and Practice, University of East Anglia, Norwich

  9. 9

    Section of Psychological Medicine, University of Glasgow, Glasgow

  10. 10

    Department of Psychiatry, University of Cambridge, Cambridge, UK

*Professor Anthony P. Morrison, School of Psychological Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Email: anthony.p.morrison@manchester.ac.uk

Publication History

  1. Issue published online: 27 JAN 2011
  2. Article first published online: 27 JAN 2011
  3. Accepted 22 September 2010

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Keywords:

  • at-risk mental state;
  • cognitive therapy;
  • early intervention;
  • prodrome;
  • psychosis

Abstract

Aims: Much research has begun to focus on the identification of people who are at high risk of developing psychosis, and clinical services have been initiated for this population. However, only a small number of studies have reported on the efficacy of interventions for preventing or delaying the onset of psychosis. The results of prior work suggest that cognitive therapy (CT) may be an effective, well-tolerated treatment. We report on the rationale and design for a large-scale, multi-site randomized, controlled trial of CT for people who are assessed to be at high risk of psychosis because of either state or state-plus-trait risk factors.

Methods: The study employs a single-blind design in which all participants receive frequent mental-state monitoring, which will efficiently detect transition to psychosis, and half are randomized to weekly sessions of CT for up to 6 months. Participants will be followed-up for a minimum of 12 months and to a maximum of 2 years.

Results: We report the characteristics of the final sample at baseline (n = 288).

Conclusions: Our study aimed to expand the currently limited evidence base for best practice in interventions for individuals at high risk of psychosis.

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