Pharmacotherapy and clinical characteristics of ultra-high-risk for psychosis according to conversion status: a naturalistic observational study
Article first published online: 26 OCT 2011
© 2011 Blackwell Publishing Asia Pty Ltd
Early Intervention in Psychiatry
Volume 6, Issue 1, pages 30–37, February 2012
How to Cite
Kim, E., Jang, J. H., Park, H.-Y., Shim, G., Hwang, J. Y., Kim, S. N. and Kwon, J. S. (2012), Pharmacotherapy and clinical characteristics of ultra-high-risk for psychosis according to conversion status: a naturalistic observational study. Early Intervention in Psychiatry, 6: 30–37. doi: 10.1111/j.1751-7893.2011.00295.x
- Issue published online: 24 JAN 2012
- Article first published online: 26 OCT 2011
- Received 11 November 2010; accepted 17 April 2011
- primary prevention;
Aim: To explore the differences in pharmacotherapy and clinical characteristics of individuals at ultra-high-risk (UHR) for psychosis according to the conversion status, we analyzed the data for UHR patients seen at the Seoul Youth Clinic.
Methods: This was a naturalistic observational study. We obtained clinical data, including demographic data, presenting complaint, duration of psychiatric symptoms, diagnosis and scores on clinical rating scales from individual records in the Seoul Youth Clinic. Prescription data were obtained from electronic medical records.
Results: As of April 1, 2010, a total of 78 people were registered as being UHR for psychosis in the Seoul Youth Clinic. Patients commonly presented with paranoid ideas and anxiety. On entry to the Seoul Youth Clinic, 81% of the UHR group were diagnosed as having psychiatric disorders according to DSM-IV criteria. Of the 67 individuals who did not drop out of the Seoul Youth Clinic, 14 converted to psychosis. The mean time to conversion was 412 days post baseline examination. The mean duration of psychiatric symptoms before clinic presentation was shorter in the converter group than in the non-converter group. There were no differences in baseline scores on clinical rating scales between the two groups. Antipsychotics were commonly prescribed for UHR patients in the Seoul Youth Clinic, with the converter group exposed to antipsychotics for a longer period and at higher doses than the non-converter group.
Conclusions: In a naturalistic setting, the different pattern of exposure to antipsychotics between the converter and non-converter groups calls attention to the effects of antipsychotics on conversion to psychosis.