This paper is based on a study that is being carried out at: Institute of Mental Health, Early Psychosis Intervention, Buangkok Green, Medical Park, 10 Buangkok View, Singapore 539747.
The Singapore flagship programme in translational and clinical research in psychosis
Article first published online: 27 OCT 2011
© 2011 Blackwell Publishing Asia Pty Ltd
Early Intervention in Psychiatry
Volume 5, Issue 4, pages 290–300, November 2011
How to Cite
Chong, S.-A., Campbell, A., Chee, M., Liu, J., Marx, C., McGorry, P., Subramaniam, M., Yung, A. and Keefe, R. S.E. (2011), The Singapore flagship programme in translational and clinical research in psychosis. Early Intervention in Psychiatry, 5: 290–300. doi: 10.1111/j.1751-7893.2011.00304.x
- Issue published online: 27 OCT 2011
- Article first published online: 27 OCT 2011
- Received 25 July 2010; accepted 28 March 2011
- ultra-high risk
Aim: This paper describes the rationale, aims and development of the Singapore Translational and Clinical Research in Psychosis, which is a 5-year programme.
Methods: The authors provide a selective review of the pertinent findings from the clinical, neuropsychological, genetics and neuroimaging studies on high-risk population and how they were factored in the hypotheses and design of this translational clinical research programme.
Results: This programme, which draws upon the previous work of various groups and the experience of the investigators of this consortium, comprises three interlinked studies. The first is a genome-wide association and copy number variation analysis using the diagnostic phenotype of schizophrenia and cognitive phenotypes, and a joint genome-wide analysis performed by combining our data with other datasets to increase the power to detect genetic risk factors. The second is a prospective study of a large group of individuals who are assessed to be at ultra-high risk of psychosis, and the third is a randomized controlled trial to improve neurocognition in patients with schizophrenia.
Conclusion: The convergence of various factors including the unique structured characteristics of the Singaporean society, the presence of political will with availability of funding and the established research infrastructure make it possible to accrue the sample size for adequate power to elucidate biomarkers of disease risk and resilience.