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Effectiveness of aripiprazole in adolescents and young adults with schizophrenia spectrum disorders: comparison of first-episode to recurrent psychosis

Authors

  • Yu-Shu Huang,

    1. Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital
    2. School of Medicine, Chang Gung University, Taoyuan
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  • Chin-Bin Yeh,

    1. Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei
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  • Ching-Shu Tang,

    1. Department of Child and Adolescent Psychiatry, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung
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  • Chih-Ken Chen,

    1. School of Medicine, Chang Gung University, Taoyuan
    2. Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan
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  • Wen-Jiun Chou,

    1. School of Medicine, Chang Gung University, Taoyuan
    2. Department of Child and Adolescent Psychiatry, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung
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  • Miao-Chun Chou,

    1. School of Medicine, Chang Gung University, Taoyuan
    2. Department of Child and Adolescent Psychiatry, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung
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  • Yu-Yu Wu,

    1. Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital
    2. School of Medicine, Chang Gung University, Taoyuan
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  • Hsin-Yi Liang,

    1. Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital
    2. School of Medicine, Chang Gung University, Taoyuan
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  • Liang-Jen Wang

    Corresponding author
    1. School of Medicine, Chang Gung University, Taoyuan
    • Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan
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Corresponding author: Dr Liang-Jen Wang, Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, No.200 Avenue 208 Ji-Jin 1st Raod, Keelung 204, Taiwan. Email: wangliangjen@gmail.com

Abstract

Aims

The study aims to determine the clinical outcomes of aripiprazole treatment in adolescents and young adults with schizophrenia spectrum disorders.

Methods

This was a 24-week, observational, prospective study. Patients with schizophrenia spectrum disorders were prescribed a daily dose of 5 mg to 30 mg of aripiprazole. Effectiveness was assessed by the change from baseline in psychotic symptoms and quality of life.

Results

Forty-two patients with a mean age of 18.1 ± 3.7 years were recruited. Eighteen were experiencing the first episode of psychosis (FEP), whereas the remaining 24 were non-FEP. Psychotic symptoms, but not quality of life, improved globally from baseline scores by the endpoint of the study (effect size = 0.44). Compared with non-FEP patients, FEP patients had greater improvements (effect size = 0.45) in some clinical outcome dimensions during the 24-week aripiprazole treatment.

Conclusion

We observed significant improvements of medium effect sizes in psychotic symptoms of patients with schizophrenia spectrum disorders within a naturalistic clinical setting, especially for FEP patients.

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