Screening for bipolar disorder in adolescents with the Mood Disorder Questionnaire – Adolescent version (MDQ-A) and the Child Bipolar Questionnaire (CBQ)
Article first published online: 26 AUG 2012
© 2012 Blackwell Publishing Asia Pty Ltd
Early Intervention in Psychiatry
How to Cite
Miguez, M., Weber, B., Debbané, M., Balanzin, D., Gex-Fabry, M., Raiola, F., Barbe, R. P., Vital Bennour, M., Ansermet, F., Eliez, S. and Aubry, J.-M. (2012), Screening for bipolar disorder in adolescents with the Mood Disorder Questionnaire – Adolescent version (MDQ-A) and the Child Bipolar Questionnaire (CBQ). Early Intervention in Psychiatry. doi: 10.1111/j.1751-7893.2012.00388.x
- Article first published online: 26 AUG 2012
- Manuscript Accepted: 26 MAY 2012
- Manuscript Received: 17 NOV 2011
- bipolar disorder;
- early diagnosis;
Screening instruments for bipolar disorders (BDs) in children and adolescents have been developed recently. The present study examined performances of the French versions of the Mood Disorder Questionnaire – Adolescent version (MDQ-A) and Child Bipolar Questionnaire (CBQ) in a sample of in- and outpatients.
Seventy-six adolescents (age 13–18) and parents first completed the MDQ-A (adolescent and parent versions) and CBQ screening instruments. About 3 weeks later, they had a diagnostic interview with the Kiddie-Schedule for Affective Disorders and Schizophrenia – Present and Lifetime (K-SADS-PL), and the adolescent MDQ-A self-report was completed a second time.
Eight of 76 patients (10.5%) met K-SADS-PL diagnostic criteria for BD. Test–retest reliability of the adolescent MDQ-A self-report was moderate (kappa = 0.66), whereas agreement between adolescent and parent reports was poor (kappa = 0.07). Sensitivity and specificity of the MDQ-A with respect to K-SADS-PL were 75.0% and 57.4% for the adolescent version, and 87.5% and 63.2% for the parent version. Corresponding figures were 50.0% and 73.5% for the CBQ. All three screening instruments had low positive predictive values (17.1% for the MDQ-A adolescent version; 21.9% for the MDQ-A parent version; 18.2% for the CBQ), whereas negative predictive values were higher than 90%.
The present study points to modest performances of the MDQ-A and CBQ to detect BDs in adolescents, with diagnostic criteria for BD being unmet for a majority of patients who screened positive.