• Open Access

Genomic engineering

An annotated selection of World Wide Web sites relevant to the topics in Microbial biotechnology

Authors

  • Lawrence P. Wackett

    1. McKnight Professor
      BioTechnology Institute
      Department of Biochemistry
      Molecular Biology and Biophysics
      University of Minnesota
      St Paul, MN 55108, USA
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What is genomic engineering?

http://www.cheme.columbia.edu/pages/academics/grad/genomic_engineering.html

This page on a Departmental website offers a nice discussion of genome engineering that is useful for students and others.

Genome engineering goes high speed

http://www.wired.com/wiredscience/2009/07/cellfactories/

This popular science description of genome engineering is entertaining and descriptive.

Genomic engineering: from sequence to function

http://www.ece.drexel.edu/gailr/class_papers/fitchSOKHANSANJ.pdf

This material on nucleic acids and genomics was written for engineers and provides a fundamental but interesting tutorial on the subject.

Reading and writing genomes: lecture by George Church

http://www.scivee.tv/node/10578

This freely available web lecture at the Joint Genome Institute by George Church in 2009 deals directly with techniques in genome engineering.

Reduced genome strain for threonine production

http://www.microbialcellfactories.com/content/8/1/2

This paper deals with a key concept in genome engineering; specifically, genome reduction to remove unneeded functions and to enhance desirable cell phenotypes for biotechnology.

Genomic engineering Lactococcus lactis

http://www.nisr.or.jp/englishHP/report2007/NISR07hashimoto.pdf

Genome deletion libraries are key tools for the genomic analysis and engineering of Escherichia coli and Bacillus subtilis. This web posting deals with the methods of making these libraries in Lactococcus lactis.

Genome comparisons of Bacillus subtilis: lecture by Ashlee Earl

http://www.scivee.tv/node/11216

This freely available web lecture at the Joint Genome Institute by Ashlee Earl in 2009 discusses genome differences among strains of the same bacterial genus and species.

Metabolic flux analysis for bacteria with genome sequences

http://www.geg.ufsc.br/index.php?option=com_content&task=view&id=16&Itemid=41

A major goal of genomic engineering is for metabolic engineering purposes. Thus, the development of metabolic and genomic analysis tools must go hand in hand.

Metabolic engineering in the post genomic era

http://www.horizonbioscience.com/abs/absmet.html

This page dealing with a book on genomic and metabolic engineering has the chapter abstracts posted online.

Let E. coli teach genome engineering

http://www.genetics.org/cgi/reprint/183/4/1205

This paper focuses on transposons as important vehicles of naturally occurring genomic engineering.

Genome modification by bacteriophage

http://cee.mit.edu/node/1070

This page discusses studies into how bacteriophage infection, while killing some members of a population, may modify the genomes of others.

Genomics awardee workshop

http://genomicscience.energy.gov/pubs/1allabstracts/2008abstracts/index.shtml

This outline of a genomic workshop provides useful links.

Synthetic genome

http://www.astrobio.net/pressrelease/3502/synthetic-genome

This site has interesting commentary by leading experts on the microbial synthetic genome projects.

Genome engineering scientific network

http://www.genome-engineering.com/

This site contains entertaining stories and links dealing with genomics and genomic engineering.

Genome engineering: open netware

http://openwetware.org/wiki/20.109(F07):_Genome_engineering_assessment

This open-ware site contains raw laboratory notes dealing with genomic engineering topics.

Engineering synthetic microbial metabolism

http://www.hindawi.com/journals/jbb/2010/459760.html

This review article gives a nice overview of systems biology and genomic engineering.

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