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Bacterial riboswitches

An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology

Authors

  • Lawrence P. Wackett

    1. McKnight Professor, BioTechnology Institute, Department of Biochemistry Molecular Biology and Biophysics, University of Minnesota, St Paul, MN 55108, USA
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Riboswitches: Wikipedia

http://en.wikipedia.org/wiki/Riboswitch

This wikipedia entry provides an extensive description of natural and engineered riboswitches. Most known riboswitches have been found in bacteria.

Improved riboswitch for atrazine

https://etd.library.emory.edu/view/record/pid/emory:92rgn

This webpage provides a link to an electronic thesis file describing a riboswitch that responds to the herbicide atrazine.

Synthetic riboswitches in bacteria

http://www.asm.org/index.php/news-room/synthetic-riboswitches-turn-on-bacterial-genes.html?title=Synthetic+Riboswitches+Turn+On+Bacterial+Genes

This web article discusses synthetic riboswitches. These are tools that researchers can use to control bacterial metabolism.

Screening for synthetic riboswitches

https://etd.library.emory.edu/view/record/pid/emory:50s1p

The development of synthetic riboswitches requires the ability to screen aptamers for the ability to bind molecules of interest. The use of the method to develop a riboswitch for the natural product theophylline is described.

Riboswitch references

http://www.citeulike.org/user/chrisvanlang

This page contains an extensive list of references related to ribozymes and riboswitches.

Riboswitches comprising off-on switch

http://pubs.rsc.org/en/Content/ArticleLanding/2010/CC/c0cc01438a

On and off riboswitches were deployed in tandem to produce regulation that mimics an electronic band-pass filter.

Design principles for riboswitch function

http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000363

This web article describes modeling for the effective design of synthetic riboswitches.

Theophylline riboswitch

http://gcat.davidson.edu/mediawiki-1.15.0/index.php/Riboswitches

This page provides a good overview of riboswitches and has useful graphics.

Synthetic RNA switches: Blog

http://scienceblogs.com/oscillator/2010/01/synthetic_rna_switches.php

This blog page provides a discussion of a paper and a good overview of riboswitches.

Riboswitch citations

http://www.microbugs.org/showcitationlist.php?keyword=riboswitches

This page contains an extensive list of references on mostly natural riboswitches.

Riboswitch use patent

http://ip.com/patent/US7794931

This page contains a patent on riboswitches. As described, riboswitches can be used to make biosensors, engineer metabolism and carry out gene therapy.

Switching off drug resistance

http://mag.digitalpc.co.uk/olive/ode/hchembiol/LandingPage/LandingPage.aspx?href=SENIQm9kZS8yMDEwLzA4LzAx&pageno=Mw..&entity=QXIwMDMwMw..&view=ZW50aXR5

A ribozyme has been explored to block bacterial resistance to beta-lactam antibiotics.

Purine riboswitch Facebook page

http://www.facebook.com/pages/Purine-riboswitch/140223079337851

This Facebook page describes ribozymes that recognize purine nucleotides. There are links to Protein Databank files to these ribozymes.

Riboswitch finder

http://riboswitch.bioapps.biozentrum.uni-wuerzburg.de/server.html

This database allows one to screen sequences for potential function as ribozymes.

Of terms in biology: Riboswitch

http://schaechter.asmblog.org/schaechter/2011/06/of-terms-in-biology-riboswitch.html

This description of bacterial riboswitches is from the Microbe blog. Links to additional information are provided.

New functions of riboswitches

http://gradworks.umi.com/34/40/3440596.html

This page provides a link to a thesis describing novel functions of riboswitches. With widespread genome sequencing, more types of riboswitches are being identified in bacteria.

Folding kinetics of riboswitches: YouTube video

http://www.youtube.com/watch?v=K3013N318Hk

This link is to a lecture on riboswitches.

Ancillary