• Anderson, D.G., and McKay, L.L. (1983) Simple and rapid method for isolating large plasmid DNA from lactic streptococci. Appl Environ Microbiol 46: 549552.
  • Carnet-Ripoche, A., Chollet, E., Peyrol, E., and Sebti, I. (2006) Evaluation of nisin diffusion in a polysaccharide gel: influence of agarose and fatty content. Innov Food Sci Emerg Technol 7: 107111.
  • Carroll, J., Field, D., O'Connor, P.M., Cotter, P.D., Coffey, A., Hill, C., et al. (2010) Gene encoded antimicrobial peptides, a template for the design of novel anti-mycobacterial drugs. Bioeng Bugs 1: 408412.
  • Cortés, J., Appleyard, A.N., and Dawson, M.J. (2009) Chapter 22. Whole-cell generation of lantibiotic variants. Methods Enzymol 458: 559574.
  • Cotter, P.D., Hill, C., and Ross, R.P. (2005a) Bacteriocins: developing innate immunity for food. Nat Rev Microbiol 3: 777788.
  • Cotter, P.D., Hill, C., and Ross, R.P. (2005b) Bacterial lantibiotics: strategies to improve therapeutic potential. Curr Protein Pept Sci 6: 6175.
  • Dalton, C.B., Austin, C.C., Sobel, J., Hayes, P.S., Bibb, W.F., Graves, L.M., et al. (1997) An outbreak of gastroenteritis and fever due to Listeria monocytogenes in milk. N Engl J Med 336: 100105.
  • Field, D., O'Connor, P.M., Cotter, P.D., Hill, C., and Ross, R.P. (2008) The generation of nisin variants with enhanced activity against specific Gram-positive pathogens. Mol Microbiol 69: 218230.
  • Field, D., Quigley, L., O'Connor, P.M., Rea, M.C., Daly, K., Cotter, P.D., et al. (2010a) Studies with bioengineered Nisin peptides highlight the broad spectrum potency of Nisin V. Microb Biotechnol 3: 473486.
  • Field, D., Hill, C., Cotter, P.D., and Ross, R.P. (2010b) The dawning of a ‘Golden era’ in lantibiotic bioengineering. Mol Microbiol 78: 10771087.
  • Holo, H., and Nes, I.F. (1995) Transformation of Lactococcus by electroporation. Methods Mol Biol 47: 195199.
  • de Juarez, L.J., Jozala, A.F., Mazzola, P.G., and Penna, T.C.V. (2009) Nisin biotechnological production and application: a review. Trends Food Sci Technol 20: 146154.
  • Kuipers, O.P., Beerthuyzen, M.M., Siezen, R.J., and De Vos, W.M. (1993) Characterization of the nisin gene cluster nis-ABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity. Eur J Biochem 216: 281291.
  • de Kwaadsteniet, M., ten Doeschate, K., and Dicks, L.M.T. (2008) Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsp. lactis isolate from freshwater catfish (Clarias gariepinus). Appl Environ Microbiol 74: 547549.
  • Lubelski, J., Rink, R., Khusainov, R., Moll, G.N., and Kuipers, O.P. (2008) Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cell Mol Life Sci 65: 455476.
  • Mulders, J.W.M., Boerrigter, I.J., Rollema, H.S., Siezen, R.J., and de Vos, W.M. (1991) Identification and characterization of the lantibiotic nisin Z, a natural nisin variant. Eur J Biochem 201: 581584.
  • Piper, C., Hill, C., Cotter, P.D., and Ross, R.P. (2010) Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z. Microb Biotechnol 4: 375382.
  • Proctor, M.E., Brosch, R., Mellen, J.W., Garrett, L.A., Kaspar, C.W., and Luchansky, J.B. (1995) Use of pulsed-field gel electrophoresis to link sporadic cases of invasive listeriosis with recalled chocolate milk. Appl Environ Microbiol 61: 31773179.
  • Rink, R., Wierenga, J., Kuipers, A., Kluskens, L.D., Driessen, A.J., Kuipers, O.P., and Moll, G.N. (2007) Dissection and modulation of the four distinct activities of nisin by mutagenesis of rings A and B and by C-terminal truncation. Appl Environ Microbiol 73: 58095816.
  • Rollema, H.S., Kuipers, O.P., Both, P., de Vos, W.M., and Siezen, R.J. (1995) Improvement of solubility and stability of the antimicrobial peptide nisin Z by protein engineering. Appl Environ Microbiol 61: 28732878.
  • Sebti, I., Blanc, D., Carnet-Ripoche, A., Saurel, R., and Coma, V. (2004) Experimental study and modeling of nisin diffusion in agarose gels. J Food Eng 63: 185190.
  • Wiedemann, I., Bottiger, T., Bonelli, R.R., Wiese, A., Hagge, S.O., Gutsmann, T., et al. (2006) The mode of action of the lantibiotic lacticin 3147- a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II. Mol Microbiol 61: 285296.
  • Wirawan, R.E., Klesse, N.A., Jack, R.W., and Tagg, J.R. (2006) Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol 72: 11481156.
  • Yuan, J., Zhang, Z.Z., Chen, X.Z., Yang, W., and Huan, L.D. (2004) Site-directed mutagenesis of the hinge region of nisin Z and properties of nisin Z mutants. Appl Microbiol Biotechnol 64: 806815.
  • Zendo, T., Fukao, M., Ueda, K., Higuchi, T., Nakayama, J., and Sonomoto, K. (2003) Identification of the lantibiotic nisin Q, a new natural nisin variant produced by Lactococcus lactis 61-14 isolated from a river in Japan. Biosci, Biotechnol, Biochem 67: 16161619.