ABSTRACT: This paper reports on the current assessment of climate impacts on water resources, including aquatic ecosystems, agricultural demands, and water management, in the U.S. Great Plains. Climate change in the region may have profound effects on agricultural users, aquatic ecosystems, and urban and industrial users alike. In the central Great Plains Region, the potential impacts of climate changes include changes in winter snowfall and snow-melt, growing season rainfall amounts and intensities, minimum winter temperature, and summer time average temperature. Specifically, results from general circulation models indicate that both annual average temperatures and total annual precipitation will increase over the region. However, the seasonal patterns are not uniform. The combined effect of these changes in weather patterns and average seasonal climate will affect numerous sectors critical to the economic, social and ecological welfare of this region. Research is needed to better address the current competition among the water needs of agriculture, urban and industrial uses, and natural ecosystems, and then to look at potential changes. These diverse demands on water needs in this region compound the difficulty in managing water use and projecting the impact of climate changes among the various critical sectors in this region.