ABSTRACT: Using a genetic algorithm (GA), optimal intermittent pumping schedules were established to simulate pump-and-treat remediation of a contaminated aquifer with known hydraulic limitations and a water miscible contaminant, located within the Duke Forest in Durham, North Carolina. The objectives of the optimization model were to minimize total costs, minimize health risks, and maximize the amount of contaminant removed from the aquifer. Stochastic ground water and contaminant transport models were required to provide estimates of contaminant concentrations at pumping wells. Optimization model simulations defined a tradeoff curve between the pumping cost and the amount of contaminant extracted from the aquifer. For this specific aquifer/miscible contaminant combination, the model simulations indicated that pump-and-treat remediation using intermittent pumping schedules for each pumping well produced significant reductions in predicted contaminant concentrations and associated health risks at a reasonable cost, after a remediation time of two years.