Conflicts of interest The authors have declared that they have no conflicts of interest.
Hormonal factors and respiratory health in women – a review
Version of Record online: 3 SEP 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
The Clinical Respiratory Journal
Special Issue: Respiratory Epidemiologic Research
Volume 2, Issue Supplement s1, pages 111–119, October 2008
How to Cite
Real, F. G., Svanes, C., Macsali, F. and Omenaas, E. R. (2008), Hormonal factors and respiratory health in women – a review. The Clinical Respiratory Journal, 2: 111–119. doi: 10.1111/j.1752-699X.2008.00093.x
- Issue online: 3 SEP 2008
- Version of Record online: 3 SEP 2008
- Accepted: 28 March 2008
- sex hormones;
- irregular menstruation;
Sex hormones appear to play an important role in the lung health of women. This is, however, poorly understood and, in most aspects, poorly investigated; and the literature has been contradictory and confusing. This review presents recent research concerning the involvement of sex hormones in respiratory health of adult women, using the population surveys European Community Respiratory Health Survey and Respiratory Health in Northern Europe.
Respiratory health varied substantially according to hormonal and metabolic conditions. First, menopause was associated with lower lung function and more respiratory symptoms, especially among lean women. Second, hormonal replacement therapy (HRT) was associated with increased risk for asthma and wheeze; also, this association was particularly strong among lean women. Third, women with irregular menstruations in fertile age had more asthma, particularly allergic asthma, and reduced lung function, independently of body mass index (BMI) and physical activity. The findings were consistent across cultural and geographical borders. Our studies revealed that considering interplay between hormonal and metabolic factors is a clue to understand the effects of female sex hormones on the airways. A BMI of around 24–25 kg/m2 appeared to be optimal; women with this BMI had no increase in respiratory health problems when reaching menopause or using HRT, and women in fertile age with this BMI had optimal lung function independently of menstrual status.
In conclusion, female sex hormones appear to play a most important role for lung health in women. Further research on effects of sex hormones on the airways should take into account potential interplay with metabolic factors.
Please cite this paper as: Real FG, Svanes C, Macsali F and Omenaas ER. Hormonal factors and respiratory health in women – a review. The Clinical Respiratory Journal 2008; 2: 111–119.