Authorship and contributorship: OT, OO, DG, AO, AK and CS performed research, collected data, analyzed data, and wrote the paper.
Growth of a solitary pulmonary nodule after 6 years diagnosed as oncocytic carcinoid tumour with a high 18-fluorodeoxyglucose (18F-FDG) uptake in positron emission tomography-computed tomography (PET-CT)
Article first published online: 16 JAN 2012
© 2011 Blackwell Publishing Ltd
The Clinical Respiratory Journal
Volume 7, Issue 1, pages e1–e5, January 2013
How to Cite
Turan, O., Ozdogan, O., Gurel, D., Onen, A., Kargi, A. and Sevinc, C. (2013), Growth of a solitary pulmonary nodule after 6 years diagnosed as oncocytic carcinoid tumour with a high 18-fluorodeoxyglucose (18F-FDG) uptake in positron emission tomography-computed tomography (PET-CT). The Clinical Respiratory Journal, 7: e1–e5. doi: 10.1111/j.1752-699X.2011.00274.x
Conflict of interest: The authors have stated explicitly that there are no conflicts of interest in connection with this article.
- Issue published online: 26 MAR 2013
- Article first published online: 16 JAN 2012
- Accepted manuscript online: 30 NOV 2011 07:37AM EST
- Received: 24 March 2011; Revision requested: 18 August 2011; Accepted: 07 November 2011
- 18-fluorodeoxyglucose positron emission tomography scan;
- carcinoid syndrome;
- neuroendocrine tumour
Introduction: Pulmonary carcinoid tumour is low-grade neuroendocrine malignancy that is seen 1%–2% of all lung neoplasms. Oncocytic carcinoid type is a rarely seen variant of pulmonary carcinoids. As carcinoid tumours have hypometabolic activity, they usually have lower 18-fluorodeoxyglucose (18F-FDG) uptake than expected for lung carcinoma on positron emission tomography (PET).
Case Report: A 45-year-old non-smoking man had a stable solitary pulmonary nodule followed for 6 years; the tumour remained the same size (1.5 × 2.4 cm) during this period. The patient was admitted to the hospital with complaints of repetitive sneezing and rhinorrhoea. He also experienced flushing and bronchospasm. His chest X-ray revealed a minimal increase in the size of the solitary pulmonary nodule (2.0 × 2.8 cm). In PET-computed tomography (CT), the parenchymal nodule in the anterior segment of the right lung had a standard uptake value of 38.0 mg/mL, which was interpreted as a malignant nodule. He underwent fibre-optic bronchoscopy, but cytology showed no evidence of malignancy. Right upper and middle bilobectomy was performed, and a pulmonary carcinoid tumour with an oncocytic subgroup was diagnosed. The diagnosis of carcinoid syndrome was further confirmed by an elevated 24-h urinary excretion of 5-hydroxyindoleacetic acid.
Conclusion: We present a rare case of an oncocytic carcinoid tumour with an increase in the size of a solitary pulmonary nodule after 6 years' follow-up. In addition, PET-CT showed a very high 18F-FDG uptake in this patient, which is an unexpected finding with a pulmonary carcinoid tumour.
Please cite this paper as: Turan O, Ozdogan O, Gurel D, Onen A, Kargi A and Sevinc C. Growth of a solitary pulmonary nodule after 6 years diagnosed as oncocytic carcinoid tumour with a high 18F-FDG uptake in positron emission tomography-computed tomography (PET-CT). Clin Respir J 2013; 7: e1–e5.